Long-lived plasma cells: a mechanism for maintaining persistent antibody production.

Current opinion in immunology ·Vol. 10 ·No. 3 ·1998-06-00 ·Pages 252-8

Slifka MK, Ahmed R

Abstract

Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibody responses.

MeSH Terms

Animals Antibody Formation Antigen-Antibody Complex/immunology B-Lymphocyte Subsets/immunology Cell Movement Cellular Senescence Chronic Disease Cross Reactions Dendritic Cells/immunology Humans Immunoglobulin Idiotypes/immunology Immunologic Memory/immunology Lymphocyte Activation Mice Models, Immunological Plasma Cells/cytology,immunology Vaccination

Chemicals

Antigen-Antibody Complex Immunoglobulin Idiotypes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Slifka M K

Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92122, USA.

Ahmed R

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/s0952-7915(98)80162-3

Published

1998-06-00

Pages

252-8

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/s0952-7915(98)80162-3 View journal details

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