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PMID: 965085 Published · ppublish English Comparative Study Journal Article

Comparison of replication of adenovirus type 2 and type 4 in human lymphocyte cultures.

Infection and immunity ·Vol. 14 ·No. 3 ·1976-09-00 ·Pages 618-22

Lambriex M, Van der Veen J

Abstract

Adenovirus type 2 was capable of replicating in purified lymphocyte cultures from human adenoid specimens. Phytohemagglutinin stimulation enhanced the replication of virus. Viral titers of 103 to 104 50% tissue culture infective doses per ml were reached after 4 to 8 days. Only 1 to 3 per 106 cells were found to produce virus. In contrast, there was no evidence that lymphocyte cultures could support the replication of adenovirus type 4. The life span of cultures infected with type 2 or 4 was not reduced. The possibility that lymphocytes infected with virus play a role in initiating natural, persisting adenovirus infections of human adenoids is discussed.

MeSH Terms
Adenoids/microbiology Adenoviridae/growth & development Cell Survival Cells, Cultured Humans Lectins/pharmacology Lymphocytes/microbiology Time Factors Virus Replication
Chemicals
Lectins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lambriex M
Van der Veen J
References (20)
20 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.14.3.618-622.1976
Published
1976-09-00
Pages
618-22
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420930
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.14.3.618-622.1976 PMC Full Text View journal details
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