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PMID: 965103 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Characteristics of guinea pig IgE.

International archives of allergy and applied immunology ·Vol. 51 ·No. 4 ·1976-00-00 ·Pages 416-28

Ovary Z, Kaplan B, Kojima S

Abstract

Anti-dinitrophenyl (DNP) IgE antibody was produced in guinea pigs (GP) by immunization and repeated boosters with 1 mug DNP-Ascaris extract in A1 (OH)3. The isoelectric point was determined to be 6.48 and the molecular weight to be 185,000 daltons. In absorbtion chromatography, rabbit anti-GPIgG1 could not absorb the anaphylactic activity of the IgE. The activity of IgE was destroyed by heating at 56 degrees C for 1 h. IgE persisted in the skin for at least 3 weeks.

MeSH Terms
Animals Chromatography, Affinity Chromatography, DEAE-Cellulose Chromatography, Gel Female Guinea Pigs Immunoglobulin E/biosynthesis Immunoglobulin G/biosynthesis Isoelectric Focusing Passive Cutaneous Anaphylaxis
Chemicals
Immunoglobulin G Immunoglobulin E
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ovary Z
Kaplan B
Kojima S
Article Info
Journal
International archives of allergy and applied immunology
Abbr.
Int Arch Allergy Appl Immunol
ISSN
0020-5915
DOI
10.1159/000231616
Published
1976-00-00
Pages
416-28
Language
English
Region
Switzerland
NLM ID
0404561
Subset
IM
External Links
PubMed source DOI: 10.1159/000231616
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