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PMID: 9651253 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Visualization of specific B and T lymphocyte interactions in the lymph node.

Science (New York, N.Y.) ·Vol. 281 ·No. 5373 ·1998-07-03 ·Pages 96-9

Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK

Abstract

Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.

MeSH Terms
Adoptive Transfer Animals Antibody Formation Antigen Presentation B-Lymphocytes/cytology,immunology CD4-Positive T-Lymphocytes/cytology,immunology CD40 Ligand Cell Movement Dendritic Cells/immunology Germinal Center/immunology Immunization Immunoglobulin M/analysis Lymph Nodes/cytology,immunology Lymphocyte Activation Membrane Glycoproteins/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Plasma Cells/immunology
Chemicals
Immunoglobulin M Membrane Glycoproteins CD40 Ligand
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Garside P
University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom.
Ingulli E
Merica R R
Johnson J G
Noelle R J
Jenkins M K
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.281.5373.96
Published
1998-07-03
Pages
96-9
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · AI27998 · United States
NIAID NIH HHS · AI35296 · United States
NIAID NIH HHS · AI39614 · United States
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1126/science.281.5373.96 View journal details
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