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PMID: 966263 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes.

The Journal of membrane biology ·Vol. 27 ·No. 4 ·1976-06-30 ·Pages 347-62

Moore LE, Neher E

Abstract

Fluctuation and relaxation analyses were performed on monazomycin-induced conductance of lipid bilayer membranes. With both methods a slow (sec) and a fast (msec) current component are apparent; however, the amplitude of the slow, voltage-dependent process is greater than that of the fast component in the step relaxation experiment and less in the fluctuation experiment. The fluctuation analysis showed principally a rapid voltage-dependent process which appears to be related to the multistate character of the conducting channel. The experimental results are interpreted in terms of a simplified kinetic model which is used to calculate relaxation and noise amplitudes.

MeSH Terms
Alamethicin Anti-Bacterial Agents Binding Sites Cholesterol Electric Conductivity Kinetics Mathematics Membranes, Artificial Models, Biological Phosphatidylcholines
Chemicals
Anti-Bacterial Agents Membranes, Artificial Phosphatidylcholines Alamethicin Cholesterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moore L E
Neher E
References (19)
19 references, click to expand
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01869145
Published
1976-06-30
Pages
347-62
Language
English
Region
United States
NLM ID
0211301
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01869145 View journal details
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