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PMID: 9671779 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A bacterial cytokine.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 15 ·1998-07-21 ·Pages 8916-21

Mukamolova GV, Kaprelyants AS, Young DI, Young M, Kell DB

Abstract

Viable cells of Micrococcus luteus secrete a factor, which promotes the resuscitation and growth of dormant, nongrowing cells of the same organism. The resuscitation-promoting factor (Rpf) is a protein, which has been purified to homogeneity. In picomolar concentrations, it increases the viable cell count of dormant M. luteus cultures at least 100-fold and can also stimulate the growth of viable cells. Rpf also stimulates the growth of several other high G+C Gram-positive organisms, including Mycobacterium avium, Mycobacterium bovis (BCG), Mycobacterium kansasii, Mycobacterium smegmatis, and Mycobacterium tuberculosis. Similar genes are widely distributed among high G+C Gram-positive bacteria; genome sequencing has uncovered examples in Mycobacterium leprae and Mb. tuberculosis and others have been detected by hybridization in Mb. smegmatis, Corynebacterium glutamicum, and Streptomyces spp. The mycobacterial gene products may provide different targets for the detection and control of these important pathogens. This report is thus a description of a proteinaceous autocrine or paracrine bacterial growth factor or cytokine.

MeSH Terms
Amino Acid Sequence Bacterial Proteins Base Sequence Cytokines/chemistry,genetics,isolation & purification DNA Primers Genes, Bacterial Micrococcus luteus/chemistry,genetics Molecular Sequence Data Mycobacterium/growth & development Recombinant Proteins/chemistry,genetics,isolation & purification Sequence Homology, Amino Acid
Chemicals
Bacterial Proteins Cytokines DNA Primers Recombinant Proteins resuscitation-promoting factor, bacteria
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Mukamolova G V
Bakh Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr.33, 117071 Moscow, Russia.
Kaprelyants A S
Young D I
Young M
Kell D B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.15.8916
Published
1998-07-21
Pages
8916-21
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC21177
Subset
IM
Databases
GENBANK
Z96935
External Links
PubMed source DOI: 10.1073/pnas.95.15.8916 PMC Full Text View journal details
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