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PMID: 9704407 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The vertebrate cell kinetochore and its roles during mitosis.

Trends in cell biology ·Vol. 8 ·No. 8 ·1998-08-00 ·Pages 310-8

Rieder CL, Salmon ED

Abstract

A replicated chromosome possesses two discrete, complex, dynamic, macromolecular assemblies, known as kinetochores, that are positioned on opposite sides of the primary constriction of the chromosome. Here, the authors review how kinetochores control chromosome segregation during mitosis in vertebrates. They attach the chromosome to the opposing spindle poles by trapping the dynamic plus-ends of microtubules growing from the poles. They then produce much of the force for chromosome poleward motion, regulate when this force is applied, and act as a site for microtubule assembly and disassembly. Finally, they control the metaphase-anaphase transition by inhibiting chromatid separation until the chromatids are properly attached.

MeSH Terms
Animals Chromatids Humans Kinetochores/physiology Mitosis/physiology Signal Transduction Spindle Apparatus Vertebrates
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rieder C L
Division of Molecular Medicine, Wadsworth Center, New York State Dept of Health, Albany 12201-0509, USA. [email protected]
Salmon E D
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
0962-8924
DOI
10.1016/s0962-8924(98)01299-9
Email
[email protected]
Published
1998-08-00
Pages
310-8
Language
English
Region
England
NLM ID
9200566
PMCID
PMC4774253
Subset
IM
Grants
NIGMS NIH HHS · R01 GM040198-15 · United States
NIGMS NIH HHS · R01 GM040198 · United States
NIGMS NIH HHS · GMS 24364 · United States
NIGMS NIH HHS · R37 GM024364 · United States
NIGMS NIH HHS · GMS 40198 · United States
PHS HHS · P41-01219 · United States
External Links
PubMed source DOI: 10.1016/s0962-8924(98)01299-9 PMC Full Text View journal details
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