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PMID: 970989 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunoglobulin and complement deposition in skin of rheumatoid arthritis and systemic lupus erythematosus patients.

Annals of the rheumatic diseases ·Vol. 35 ·No. 4 ·1976-08-00 ·Pages 321-6

Schroeter AL, Conn DL, Jordon RE

Abstract

Rheumatoid arthritis (RA) was differentiated from systemic lupus erythematosus (SLE) by direct immunofluorescent techniques on skin specimens, using monospecific antisera for IgG, IgM, C3, C1q, properdin, and fibrin. Of 30 patients with RA studied, 20 had dermal vessel deposits of immunoglobulins and complement components in unaffected skin without the characteristic dermal-epidermal junctional fluorescence of SLE. Of 24 SLE patients studied, 24 had granular deposits of immunoglobulins and complement components in unaffected skin at the dermal-epidermal junction.

MeSH Terms
Arthritis, Rheumatoid/immunology Complement C1/analysis Complement C3/analysis Complement System Proteins/analysis Fibrin/analysis Humans Immunoglobulin G/analysis Immunoglobulin M/analysis Immunoglobulins/analysis Lupus Erythematosus, Systemic/immunology Middle Aged Properdin/analysis Skin/immunology
Chemicals
Complement C1 Complement C3 Immunoglobulin G Immunoglobulin M Immunoglobulins Properdin Fibrin Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schroeter A L
Conn D L
Jordon R E
References (26)
26 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.35.4.321
Published
1976-08-00
Pages
321-6
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1007389
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.35.4.321 PMC Full Text View journal details
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