Home LiteratureArticle Details
PMID: 9716663 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Differential expression of the zinc finger gene Zfp105 during spermatogenesis.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 9 ·No. 9 ·1998-09-00 ·Pages 758-62

Przyborski SA, Knowles BB, Handel MA, Gurwitch SA, Ackerman SL

Abstract

We report the isolation of Zfp105, the mouse homolog of the human ZNF35 zinc finger gene. Zfp105 and ZNF35 are highly conserved at the protein and nucleotide level, and Zfp105 maps to a region of mouse Chromosome (Chr) 9 that is homologous to the human region containing ZNF35. Zpf105 is highly expressed in the testis, especially in pachytene spermatocytes and round spermatids. The possible role of this gene product in maintaining an ordered germ cell differentiation process is discussed.

MeSH Terms
Amino Acid Sequence Animals Blotting, Northern Cell Differentiation/genetics Chromosome Mapping Cloning, Molecular Conserved Sequence DNA, Complementary/analysis,isolation & purification DNA-Binding Proteins/chemistry,genetics Gene Expression Regulation, Developmental Genes Humans In Situ Hybridization Male Mice Molecular Sequence Data Organ Specificity/genetics Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Spermatogenesis/genetics Testis/cytology Zinc Fingers/genetics
Chemicals
DNA, Complementary DNA-Binding Proteins Zfp 105 protein, mouse
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Przyborski S A
The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Knowles B B
Handel M A
Gurwitch S A
Ackerman S L
Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/s003359900859
Published
1998-09-00
Pages
758-62
Language
English
Region
United States
NLM ID
9100916
Subset
IM
Grants
NCI NIH HHS · CA37225 · United States
NICHD NIH HHS · HD31376 · United States
NINDS NIH HHS · NS35900 · United States
Databases
GENBANK
AF045565
External Links
PubMed source DOI: 10.1007/s003359900859 View journal details
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