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PMID: 9725844 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila.

Genetics ·Vol. 150 ·No. 1 ·1998-09-00 ·Pages 251-63

Bhadra U, Bhadra MP, Birchler JA

Abstract

We have investigated the effect of dosage-dependent trans-acting regulators of the white eye color gene in combinations to understand their interaction properties. The consequences of the interactions will aid in an understanding of aneuploid syndromes, position-effect variegation (PEV), quantitative traits, and dosage compensation, all of which are affected by dosage-dependent modifiers. Various combinations modulate two functionally related transcripts, white and scarlet, differently. The overall trend is that multiple modifiers are noncumulative or epistatic to each other. In some combinations, developmental transitions from larvae to pupae to adults act as a switch for whether the effect is positive or negative. With position-effect variegation, similar responses were found as with gene expression. The highly multigenic nature of dosage-sensitive modulation of both gene expression and PEV suggests that dosage effects can be progressively transduced through a series of steps in a hierarchical manner.

MeSH Terms
ATP-Binding Cassette Transporters/genetics Animals DNA-Binding Proteins/genetics Drosophila/genetics Drosophila Proteins Eye Proteins Female Gene Dosage Gene Expression Insect Proteins/genetics Male Mosaicism Phenotype RNA, Messenger/genetics
Chemicals
ATP-Binding Cassette Transporters DNA-Binding Proteins Drosophila Proteins Eye Proteins Insect Proteins RNA, Messenger st protein, Drosophila w protein, Drosophila z protein, Drosophila
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bhadra U
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA.
Bhadra M P
Birchler J A
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/150.1.251
Published
1998-09-00
Pages
251-63
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1460319
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/150.1.251 PMC Full Text View journal details
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