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PMID: 9736635 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 18 ·No. 18 ·1998-09-15 ·Pages 7118-26

Thomas MJ, Watabe AM, Moody TD, Makhinson M, O'Dell TJ

Abstract

Long-term potentiation (LTP), a persistent enhancement of synaptic transmission that may be involved in some forms of learning and memory, is induced at excitatory synapses in the CA1 region of the hippocampus by coincident presynaptic and postsynaptic activity. Although action potentials back-propagating into dendrites of hippocampal pyramidal cells provide sufficient postsynaptic activity to induce LTP under some in vitro conditions, it is not known whether LTP can be induced by patterns of postsynaptic action potential firing that occur in these cells in vivo. Here we report that a characteristic in vivo pattern of action potential generation in CA1 pyramidal cells known as the complex spike burst enables the induction of LTP during theta frequency synaptic stimulation in the CA1 region of hippocampal slices maintained in vitro. Our results suggest that complex spike bursting may have an important role in synaptic processes involved in learning and memory formation, perhaps by producing a highly sensitive postsynaptic state during which even low frequencies of presynaptic activity can induce LTP.

MeSH Terms
Action Potentials/drug effects,physiology Animals Electric Stimulation Excitatory Postsynaptic Potentials/physiology Hippocampus/cytology,physiology Long-Term Potentiation/physiology Male Mice Mice, Inbred C57BL Periodicity Pyramidal Cells/chemistry,physiology Receptors, N-Methyl-D-Aspartate/physiology Synaptic Transmission/drug effects,physiology Tetrodotoxin/pharmacology Theta Rhythm
Chemicals
Receptors, N-Methyl-D-Aspartate Tetrodotoxin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Thomas M J
Interdepartmental PhD Program for Neuroscience, School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA.
Watabe A M
Moody T D
Makhinson M
O'Dell T J
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1998-09-15
Pages
7118-26
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6793261
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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