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PMID: 9768354 Published · ppublish English Journal Article Review

Size control: cell proliferation does not equal growth.

Current biology : CB ·Vol. 8 ·No. 19 ·1998-09-24 ·Pages R687-9

Su TT, O'Farrell PH

Abstract

Division subdivides mass without increasing it. So one should not expect that an increase in cell division would make an organism bigger. Both classic and recent experiments confirm this simple rationale: altering proliferation produces normally sized body structures with either especially small or exceptionally large cells.

MeSH Terms
Animals CDC2 Protein Kinase/physiology Carrier Proteins Cell Cycle Proteins/physiology Cell Division Cell Size DNA-Binding Proteins Drosophila Proteins Drosophila melanogaster/cytology,embryology,growth & development E2F Transcription Factors Embryo, Nonmammalian Growth/physiology Insect Proteins/physiology Phosphoprotein Phosphatases/physiology Pupa Retinoblastoma-Binding Protein 1 Trans-Activators Transcription Factors/deficiency,physiology Wings, Animal/cytology,embryology,growth & development cdc25 Phosphatases
Chemicals
Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins Dp transcription factor, Drosophila Drosophila Proteins E2F Transcription Factors Insect Proteins Retinoblastoma-Binding Protein 1 Trans-Activators Transcription Factors CDC2 Protein Kinase Phosphoprotein Phosphatases cdc25 Phosphatases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Su T T
Department of Biochemistry and Biophysics, University of California San Francisco 94143-0448, USA. [email protected]
O'Farrell P H
References (9)
9 references, click to expand
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Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
DOI
10.1016/s0960-9822(98)70436-1
Email
[email protected]
Published
1998-09-24
Pages
R687-9
Language
English
Region
England
NLM ID
9107782
PMCID
PMC2754256
Subset
IM
Grants
NIGMS NIH HHS · R01 GM037193 · United States
NIGMS NIH HHS · R01 GM037193-10 · United States
External Links
PubMed source DOI: 10.1016/s0960-9822(98)70436-1 PMC Full Text View journal details
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