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PMID: 9774771 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Anti-hyperactivity medication: methylphenidate and amphetamine.

Molecular psychiatry ·Vol. 3 ·No. 5 ·1998-09-00 ·Pages 386-96

Seeman P, Madras BK

Abstract

How do 'stimulants' reduce hyperactivity in children and adults? How can drugs which raise extracellular dopamine result in psychomotor slowing of hyperactive children when dopamine is known to enhance motor activity, such as in Parkinson's disease? These apparent paradoxes are the focus of this brief review on the mechanism of action of stimulant medications used in the treatment of children, and of an increasing number of adults who meet diagnostic criteria for attention deficit hyperactivity disorder.

MeSH Terms
Adult Amino Acid Sequence Amphetamine/pharmacology,therapeutic use Animals Attention Deficit Disorder with Hyperactivity/drug therapy,physiopathology Central Nervous System Stimulants/pharmacology,therapeutic use Child Dopamine/physiology Humans Methylphenidate/pharmacology,therapeutic use Models, Neurological Molecular Sequence Data Parkinson Disease/physiopathology Protein Conformation Receptors, Dopamine/physiology Receptors, Dopamine D2/chemistry,physiology Receptors, Dopamine D4 Repetitive Sequences, Amino Acid Synapses/drug effects,physiology
Chemicals
Central Nervous System Stimulants DRD4 protein, human Receptors, Dopamine Receptors, Dopamine D2 Receptors, Dopamine D4 Methylphenidate Amphetamine Dopamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Seeman P
Department of Pharmacology, University of Toronto, Canada.
Madras B K
Article Info
Journal
Molecular psychiatry
Abbr.
Mol Psychiatry
ISSN
1359-4184
DOI
10.1038/sj.mp.4000421
Published
1998-09-00
Pages
386-96
Language
English
Region
England
NLM ID
9607835
Subset
IM
Grants
NIDA NIH HHS · DA00304 · United States
NIDA NIH HHS · DA07223 · United States
NIDA NIH HHS · DA09462 · United States
Corrections
CommentIn
PMID: 9774767
External Links
PubMed source DOI: 10.1038/sj.mp.4000421 View journal details
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