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PMID: 9794765 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Extended life-span and stress resistance in the Drosophila mutant methuselah.

Science (New York, N.Y.) ·Vol. 282 ·No. 5390 ·1998-10-30 ·Pages 943-6

Lin YJ, Seroude L, Benzer S

Abstract

Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.

MeSH Terms

Amino Acid Sequence Animals Animals, Genetically Modified Base Sequence Cloning, Molecular DNA Transposable Elements Drosophila Proteins Drosophila melanogaster/genetics,physiology Female Food Deprivation GTP-Binding Proteins/chemistry,genetics,metabolism,physiology Genes, Insect Hot Temperature Insecticide Resistance Longevity/genetics Male Molecular Sequence Data Mutation Oxidative Stress Paraquat/pharmacology Receptors, Cell Surface/chemistry,genetics,metabolism,physiology Receptors, G-Protein-Coupled Signal Transduction

Chemicals

DNA Transposable Elements Drosophila Proteins Receptors, Cell Surface Receptors, G-Protein-Coupled mth protein, Drosophila GTP-Binding Proteins Paraquat

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lin Y J

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

Seroude L

Benzer S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.282.5390.943

Published

1998-10-30

Pages

943-6

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIA NIH HHS · AG12289 · United States

NEI NIH HHS · EY09278 · United States

Databases

GENBANK

AF109308

Corrections

CommentIn

PMID: 9841425

External Links

PubMed source DOI: 10.1126/science.282.5390.943 View journal details

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Extended life-span and stress resistance in the Drosophila mutant methuselah.

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