Levels of circulating nitrate/nitrite and gamma interferon not increased in uncomplicated malaria.

Infection ·Vol. 26 ·No. 5 ·1998-00-00 ·Pages 301-3

Torre D, Ferrario G, Matteelli A, Speranza F, Giola M, Pugliese A, Cantamessa C, Carosi G, Fiori GP

Abstract

The purpose of this study was to evaluate nitric oxide (NO) activity in patients with uncomplicated malaria. Lipopolysaccharide and gamma interferon (IFN-gamma) are potent inducers of NO by inducing production of NO synthase. NO activity was determined by measuring serum levels of nitrite/nitrate (metabolic end products of NO), and IFN-gamma in patients with uncomplicated malaria, mostly caused by Plasmodium falciparum. Neither serum levels of nitrite/nitrate nor of IFN-gamma were significantly increased in patients with uncomplicated malaria, especially in patients with P. falciparum infection, and in those with high parasitaemia. These results show that NO cannot play a role in uncomplicated malaria, and it is still debatable if NO production in this infection has beneficial or detrimental effects.

MeSH Terms

Adult Humans Interferon-gamma/blood Malaria/blood,parasitology Malaria, Falciparum/blood Middle Aged Nitrates/blood Nitric Oxide/blood Nitrites/blood

Chemicals

Nitrates Nitrites Nitric Oxide Interferon-gamma

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Torre D

Div. of Infectious Diseases, Regional Hospital, Varese, Italy.

Ferrario G

Matteelli A

Speranza F

Giola M

Pugliese A

Cantamessa C

Carosi G

Fiori G P

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12 references, click to expand

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Article Info

Journal

Infection

Abbr.

Infection

ISSN

0300-8126

DOI

10.1007/BF02962252

Published

1998-00-00

Pages

301-3

Language

English

Region

Germany

NLM ID

0365307

Subset

External Links

PubMed source DOI: 10.1007/BF02962252 View journal details

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Levels of circulating nitrate/nitrite and gamma interferon not increased in uncomplicated malaria.

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