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PMID: 9834413 Published · ppublish English Journal Article

Resection of locally advanced pancreatic cancer after downstaging with continuous-infusion 5-fluorouracil, mitomycin-C, leucovorin, and dipyridamole.

Todd KE, Gloor B, Lane JS, Isacoff WH, Reber HA

Abstract

Patients with locally advanced pancreatic adenocarcinoma who receive conventional therapy with radiation with 5-fluorouracil (5-FU) have median survivals ranging from 8 to 12 months. Here we report our experience with a four-drug chemotherapeutic regimen that resulted in sufficient downstaging of tumor in some patients to justify surgical reexploration and resection. From April 1991 through April 1994, 38 patients received 5-FU as a continuous infusion (200 mg/m2/day), calcium leucovorin weekly by intravenous bolus injection (30 mg/m2), mitomycin-C every 6 weeks (10 mg/m2 intravenously), and dipyridamole daily orally (75 mg) for locally advanced unresected pancreatic cancer. All of these patients were evaluable for response, toxicity, and survival. There were 14 partial responses and one complete response--a 39% response rate. The median survival for all patients was 15.5 months; the 1-year survival rate from time of initial diagnosis was 70%. Six of 15 responding patients had sufficient tumor regression to meet clinical criteria for resectability and reexploration, four of whom underwent a curative resection. The median survival of these six patients was 28 months from the time of original diagnosis. The 1-year survival was 83%, with one patient still alive and free of disease at 53 months. We believe this unique experience from a single institution justifies a prospective multi-institutional trial to evaluate the efficacy of this approach in a larger number of patients.

MeSH Terms
Administration, Oral Adult Aged Aged, 80 and over Antibiotics, Antineoplastic/administration & dosage,adverse effects Antidotes/administration & dosage Antimetabolites, Antineoplastic/administration & dosage,adverse effects Antineoplastic Combined Chemotherapy Protocols/administration & dosage,adverse effects,therapeutic use Combined Modality Therapy Dipyridamole/administration & dosage,adverse effects Disease-Free Survival Female Fluorouracil/administration & dosage,adverse effects Humans Infusions, Intravenous Injections, Intravenous Leucovorin/administration & dosage Male Middle Aged Mitomycin/administration & dosage,adverse effects Neoplasm Staging Pancreatectomy Pancreatic Neoplasms/drug therapy,pathology,surgery Phosphodiesterase Inhibitors/administration & dosage,adverse effects Prospective Studies Remission Induction Survival Rate
Chemicals
Antibiotics, Antineoplastic Antidotes Antimetabolites, Antineoplastic Phosphodiesterase Inhibitors Mitomycin Dipyridamole Leucovorin Fluorouracil
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Todd K E
Department of Surgery, UCLA School of Medicine, Los Angeles, CA, USA.
Gloor B
Lane J S
Isacoff W H
Reber H A
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Article Info
Journal
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Abbr.
J Gastrointest Surg
ISSN
1091-255X
Published
1998-00-00
Pages
159-66
Language
English
Region
United States
NLM ID
9706084
Subset
IM
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