Home LiteratureArticle Details
PMID: 9836639 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.

Science (New York, N.Y.) ·Vol. 282 ·No. 5395 ·1998-12-04 ·Pages 1890-3

Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D

Abstract

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

MeSH Terms
Adult Animals Anthracenes/pharmacology Brain/metabolism Ganglia, Sympathetic/metabolism Gene Expression Humans Indoles/pharmacology KCNQ2 Potassium Channel KCNQ3 Potassium Channel Kinetics Neurons/drug effects,physiology Oocytes Patch-Clamp Techniques Potassium/metabolism Potassium Channels/chemistry,drug effects,genetics,metabolism Potassium Channels, Voltage-Gated Pyridines/pharmacology Rats Sympathetic Nervous System/drug effects,physiology Tetraethylammonium/pharmacology Xenopus
Chemicals
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone Anthracenes Indoles KCNQ2 Potassium Channel KCNQ2 protein, human KCNQ3 Potassium Channel KCNQ3 protein, human Kcnq2 protein, rat Kcnq3 protein, rat Potassium Channels Potassium Channels, Voltage-Gated Pyridines Tetraethylammonium linopirdine Potassium
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wang H S
Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
Pan Z
Shi W
Brown B S
Wymore R S
Cohen I S
Dixon J E
McKinnon D
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.282.5395.1890
Published
1998-12-04
Pages
1890-3
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
AF110020
Corrections
CommentIn
PMID: 9874625
External Links
PubMed source DOI: 10.1126/science.282.5395.1890 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2