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PMID: 9846361 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

How important is Nramp1 in tuberculosis?

Trends in microbiology ·Vol. 6 ·No. 11 ·1998-11-00 ·Pages 441-3

North RJ, Medina E

Abstract

The assumption that the antimicrobial resistance gene Nramp1 is a major determinant of resistance of mice to infection with virulent Mycobacterium tuberculosis can now be challenged on the basis of published evidence to the contrary. It is likely that, with tuberculosis, Nramp1-determined defenses are subordinate to other defenses.

MeSH Terms

Animals Carrier Proteins/genetics,immunology Cation Transport Proteins Humans Immunity, Innate Macrophages/immunology Membrane Proteins/genetics,immunology Mice Mycobacterium bovis/immunology Mycobacterium tuberculosis/immunology Tuberculosis/immunology

Chemicals

Carrier Proteins Cation Transport Proteins Membrane Proteins natural resistance-associated macrophage protein 1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

North R J

Trudeau Institute, Saranac Lake, NY 12983, USA. [email protected]

Medina E

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/s0966-842x(98)01364-x

[email protected]

Published

1998-11-00

Pages

441-3

Language

English

Region

England

NLM ID

9310916

Subset

Grants

NIAID NIH HHS · AI-37844 · United States

NIAID NIH HHS · AI-40071 · United States

External Links

PubMed source DOI: 10.1016/s0966-842x(98)01364-x View journal details

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How important is Nramp1 in tuberculosis?

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