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PMID: 986687 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Physical dependence of opiate-like peptides.

Science (New York, N.Y.) ·Vol. 193 ·No. 4259 ·1976-09-24 ·Pages 1262-3

Wei E, Loh H

Abstract

Methionine-enkephalin and beta-endorphin, endogenous peptides with activities similar to those of opiates, were infused for 70 hours into the periaqueductal gray-fourth ventricular space of the rat brain. When challenged with a naloxone, a specific opiate antagonist, these animals manifested a typical morphine-like withdrawal syndrome. These results show that such peptides can cause physical dependence.

MeSH Terms

Animals Cerebral Cortex/drug effects Frontal Lobe Humans Ligands Male Morphine Naloxone/pharmacology Nerve Tissue Proteins Oligopeptides/administration & dosage Peptides/administration & dosage Rats Substance Withdrawal Syndrome/chemically induced Substance-Related Disorders Time Factors

Chemicals

Ligands Nerve Tissue Proteins Oligopeptides Peptides Naloxone Morphine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wei E

Loh H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.986687

Published

1976-09-24

Pages

1262-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.986687 View journal details

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Physical dependence of opiate-like peptides.

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