Tripeptide growth hormone secretagogues.

Bioorganic & medicinal chemistry letters ·Vol. 8 ·No. 7 ·1999-01-27

Yang L, Morriello G, Pan Y, Nargund R P, Barakat K, Prendergast K, Cheng K, Chan W W, Smith R G, Patchett A A

Abstract

A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide level.

Article Info

Journal

Bioorganic & medicinal chemistry letters

Abbr.

Bioorg Med Chem Lett

ISSN

0960-894X

Published

1999-01-27

Indexed

1999-01-27

Updated

2016-11-24

Language

English

Country/Region

England

NLM ID

9107377

External Links

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Tripeptide growth hormone secretagogues.

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