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PMID: 9887096 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of a novel mechanism of regulation of Ah (dioxin) receptor function.

Genes & development ·Vol. 13 ·No. 1 ·1999-01-01 ·Pages 20-5

Mimura J, Ema M, Sogawa K, Fujii-Kuriyama Y

Abstract

Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.

MeSH Terms
Amino Acid Sequence Animals Aryl Hydrocarbon Receptor Nuclear Translocator Basic Helix-Loop-Helix Transcription Factors Cloning, Molecular DNA-Binding Proteins Dimerization Gene Expression Regulation/genetics Helix-Loop-Helix Motifs/genetics Mice Molecular Sequence Data Polychlorinated Dibenzodioxins/metabolism Promoter Regions, Genetic/genetics Protein Binding/genetics Receptors, Aryl Hydrocarbon/metabolism Recombinant Fusion Proteins/genetics Repressor Proteins/chemistry,genetics Sequence Analysis, DNA Sequence Homology, Amino Acid Transcription Factors/genetics,metabolism Transcriptional Activation/genetics
Chemicals
Ahrr protein, mouse Arnt protein, mouse Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Polychlorinated Dibenzodioxins Receptors, Aryl Hydrocarbon Recombinant Fusion Proteins Repressor Proteins Transcription Factors Aryl Hydrocarbon Receptor Nuclear Translocator
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mimura J
Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.
Ema M
Sogawa K
Fujii-Kuriyama Y
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.13.1.20
Published
1999-01-01
Pages
20-5
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC316371
Subset
IM
Databases
GENBANK
AB015140
External Links
PubMed source DOI: 10.1101/gad.13.1.20 PMC Full Text View journal details
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