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PMID: 9888854 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

Science (New York, N.Y.) ·Vol. 283 ·No. 5400 ·1999-01-15 ·Pages 390-2

Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S

Abstract

Mice with a targeted gene disruption of p85alpha, a regulatory subunit of phosphoinositide 3-kinase, had impaired B cell development at the pro-B cell stage, reduced numbers of mature B cells and peritoneal CD5+ Ly-1 B cells, reduced B cell proliferative responses, and no T cell-independent antibody production. These phenotypes are nearly identical to those of Btk-/- or xid (X-linked immunodeficiency) mice. These results provide evidence that p85alpha is functionally linked to the Btk pathway in antigen receptor-mediated signal transduction and is pivotal in B cell development and functions.

MeSH Terms

Agammaglobulinaemia Tyrosine Kinase Animals Antibody Formation Antigens, Ly/analysis Antigens, T-Independent/immunology B-Lymphocyte Subsets/cytology,immunology B-Lymphocytes/cytology,immunology Bone Marrow/immunology CD5 Antigens/analysis Cell Survival Gene Targeting Genetic Linkage Immunologic Deficiency Syndromes/enzymology,genetics,immunology Lymphocyte Count Lymphoid Tissue/immunology Mice Mutation Phenotype Phosphatidylinositol 3-Kinases/genetics,metabolism Protein-Tyrosine Kinases/genetics,metabolism Signal Transduction T-Lymphocytes/immunology X Chromosome

Chemicals

Antigens, Ly Antigens, T-Independent CD5 Antigens Phosphatidylinositol 3-Kinases Protein-Tyrosine Kinases Agammaglobulinaemia Tyrosine Kinase Btk protein, mouse

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Suzuki H

Department of Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Terauchi Y

Fujiwara M

Aizawa S

Yazaki Y

Kadowaki T

Koyasu S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.283.5400.390

Published

1999-01-15

Pages

390-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.283.5400.390 View journal details

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

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