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PMID: 9892619 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.

The Journal of experimental medicine ·Vol. 189 ·No. 2 ·1999-01-18 ·Pages 371-80

Regnault A, Lankar D, Lacabanne V, Rodriguez A, Théry C, Rescigno M, Saito T, Verbeek S, Bonnerot C, Ricciardi-Castagnoli P, Amigorena S

Abstract

Dendritic cells (DCs) express several receptors for the Fc portion of immunoglobulin (Ig)G (FcgammaR), which mediate internalization of antigen-IgG complexes (immune complexes, ICs) and promote efficient major histocompatibility complex (MHC) class II-restricted antigen presentation. We now show that FcgammaRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I-restricted presentation of peptides from exogenous, IgG-complexed antigens. Both FcgammaR functions require the FcgammaR-associated gamma chain. FcgammaR-mediated MHC class I-restricted antigen presentation is extremely sensitive and specific to immature DCs. It requires proteasomal degradation and is dependent on functional peptide transporter associated with antigen processing, TAP1-TAP2. By promoting DC maturation and presentation on both MHC class I and II molecules, ICs should efficiently sensitize DCs for priming of both CD4(+) helper and CD8(+) cytotoxic T lymphocytes in vivo.

MeSH Terms
ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP Binding Cassette Transporter, Subfamily B, Member 3 ATP-Binding Cassette Transporters/immunology Animals Antigen Presentation/immunology Antigen-Antibody Complex/immunology Antigens, CD/immunology Bone Marrow/immunology Cysteine Endopeptidases/metabolism Dendritic Cells/immunology Fluorescent Antibody Technique Histocompatibility Antigens Class I/immunology Immunoglobulin G/immunology Lipopolysaccharides/pharmacology Mice Mice, Knockout Multienzyme Complexes/metabolism Ovalbumin/immunology Proteasome Endopeptidase Complex Receptors, IgG/immunology
Chemicals
ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP Binding Cassette Transporter, Subfamily B, Member 3 ATP-Binding Cassette Transporters Antigen-Antibody Complex Antigens, CD Histocompatibility Antigens Class I Immunoglobulin G Lipopolysaccharides Multienzyme Complexes Receptors, IgG TAP1 protein, human Tap1 protein, mouse Tap2 protein, mouse TAP2 protein, human Ovalbumin Cysteine Endopeptidases Proteasome Endopeptidase Complex
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Regnault A
Institut National de la Santé et de la Recherche Médicale CJF 95-01, Institut Curie, Section Recherche, 75005 Paris, France.
Lankar D
Lacabanne V
Rodriguez A
Théry C
Rescigno M
Saito T
Verbeek S
Bonnerot C
Ricciardi-Castagnoli P
Amigorena S
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.189.2.371
Published
1999-01-18
Pages
371-80
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192989
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.189.2.371 PMC Full Text View journal details
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