Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency.

Cell Division/drug effects Cell Line Cytidine Diphosphate/metabolism Deoxycytidine/metabolism Deoxycytosine Nucleotides/metabolism Deoxyguanosine/toxicity Hypoxanthines/pharmacology Immunosuppression Therapy Oxidation-Reduction Pentosyltransferases/deficiency Purine Nucleosides/toxicity Purine-Nucleoside Phosphorylase/deficiency Ribonucleotides/metabolism T-Lymphocytes/drug effects Uridine/pharmacology

Deoxycytosine Nucleotides Hypoxanthines Purine Nucleosides Ribonucleotides Deoxycytidine Cytidine Diphosphate Pentosyltransferases Purine-Nucleoside Phosphorylase Deoxyguanosine Uridine