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PMID: 9927489 Published · ppublish English Journal Article Review

The innate immune system in cystic fibrosis lung disease.

The Journal of clinical investigation ·Vol. 103 ·No. 3 ·1999-02-00 ·Pages 303-7

Bals R, Weiner DJ, Wilson JM

Abstract

暂无摘要

MeSH Terms
Antigens, Bacterial/immunology Bacterial Infections/immunology Cystic Fibrosis/genetics,immunology Cystic Fibrosis Transmembrane Conductance Regulator/genetics Humans Immunity, Innate Immunity, Mucosal/genetics,immunology Lung/immunology,microbiology
Chemicals
Antigens, Bacterial CFTR protein, human Cystic Fibrosis Transmembrane Conductance Regulator
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bals R
Institute for Human Gene Therapy, Departments of Medicine and Molecular and Cellular Engineering, The Wistar Institute, Philadelphia, Pennsylvania 19104-4268, USA.
Weiner D J
Wilson J M
References (27)
27 references, click to expand
  1. Antibiotic peptides as mediators of innate immunity.
    Curr Opin Immunol. 1992 Feb;4(1):3-7 PMID: 1596366
  2. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.
    Proc Natl Acad Sci U S A. 1991 May 1;88(9):3952-6 PMID: 2023943
  3. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
    Science. 1989 Sep 8;245(4922):1066-73 PMID: 2475911
  4. Identification of the cystic fibrosis gene: chromosome walking and jumping.
    Science. 1989 Sep 8;245(4922):1059-65 PMID: 2772657
  5. Qualitative and quantitative microbiological analysis of sputa of 102 patients with cystic fibrosis.
    Infection. 1987 Jul-Aug;15(4):270-7 PMID: 3117700
  6. Chloride impermeability in cystic fibrosis.
    Nature. 1983 Feb 3;301(5899):421-2 PMID: 6823316
  7. Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain.
    FEBS Lett. 1995 Oct 23;374(1):1-5 PMID: 7589491
  8. hBD-1: a novel beta-defensin from human plasma.
    FEBS Lett. 1995 Jul 17;368(2):331-5 PMID: 7628632
  9. Defensins.
    Pharmacol Ther. 1995 May;66(2):191-205 PMID: 7667395
  10. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface.
    Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3019-23 PMID: 7708767
  11. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis.
    BMJ. 1995 Jun 17;310(6994):1571-2 PMID: 7787647
  12. Epithelial antibiotics induced at sites of inflammation.
    Science. 1995 Mar 17;267(5204):1645-8 PMID: 7886453
  13. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections.
    Science. 1996 Jan 5;271(5245):64-7 PMID: 8539601
  14. The instructive role of innate immunity in the acquired immune response.
    Science. 1996 Apr 5;272(5258):50-3 PMID: 8600536
  15. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.
    Cell. 1996 Apr 19;85(2):229-36 PMID: 8612275
  16. Gene therapy for cystic fibrosis: challenges and future directions.
    J Clin Invest. 1995 Dec;96(6):2547-54 PMID: 8675618
  17. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.
    Eur J Biochem. 1996 Jun 1;238(2):325-32 PMID: 8681941
  18. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis.
    Cell. 1997 Feb 21;88(4):553-60 PMID: 9038346
  19. A peptide antibiotic from human skin.
    Nature. 1997 Jun 26;387(6636):861 PMID: 9202117
  20. Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis.
    Pediatr Pulmonol. 1997 Sep;24(3):173-7 PMID: 9330413
  21. Early pulmonary disease in cystic fibrosis.
    Curr Opin Pulm Med. 1997 Nov;3(6):400-3 PMID: 9391757
  22. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface.
    Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9541-6 PMID: 9689116
  23. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.
    J Clin Invest. 1998 Sep 1;102(5):874-80 PMID: 9727055
  24. Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells.
    J Clin Invest. 1998 Sep 15;102(6):1200-7 PMID: 9739054
  25. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.
    Mol Cell. 1998 Sep;2(3):397-403 PMID: 9774978
  26. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease.
    Cell. 1998 Dec 23;95(7):1005-15 PMID: 9875854
  27. The genesis of cystic fibrosis lung disease.
    J Clin Invest. 1999 Feb;103(3):309-12 PMID: 9927490
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
1999-02-00
Pages
303-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC407907
Subset
IM
Corrections
CommentIn
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