Abstract
It has been observed previously that plasma selenium and glutathione levels are subnormal in HIV-infected individuals, and plasma glutathione peroxidase activity is decreased. Under these conditions the survival rate of AIDS patients is reduced significantly. In the present study, using 75Se-labeled human Jurkat T cells, we show that the levels of four 75Se-containing proteins are lower in HIV-infected cell populations than in uninfected cells. These major selenoproteins migrated as 57-, 26-, 21-, and 15-kDa species on SDS/PAGE gels. In our earlier studies, the 57-kDa protein was purified from T cells and identified as a subunit of thioredoxin reductase. The 26- and 21-kDa proteins were identified in immunoblot assays as the glutathione peroxidase (cGPX or GPX1) subunit and phospholipid hydroperoxide glutathione peroxidase (PHGPX or GPX4), respectively. We recently purified the 15-kDa protein and characterized it as a selenoprotein of unknown function. In contrast to selenoproteins, low molecular mass [75Se]compounds accumulated during HIV infection and migrated as a diffuse band near the front of SDS/PAGE gels.
MeSH Terms
Acquired Immunodeficiency Syndrome/metabolism
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Glutathione Peroxidase/isolation & purification,metabolism
HIV Infections/metabolism
HIV-1/physiology
HeLa Cells
Humans
Jurkat Cells
Macromolecular Substances
Molecular Weight
Phospholipid Hydroperoxide Glutathione Peroxidase
Protein Biosynthesis
Proteins/isolation & purification,metabolism
Selenium Radioisotopes
Selenoproteins
T-Lymphocytes/metabolism,virology
Thioredoxin-Disulfide Reductase/isolation & purification,metabolism
Chemicals
Macromolecular Substances
Proteins
Selenium Radioisotopes
Selenoproteins
Phospholipid Hydroperoxide Glutathione Peroxidase
Glutathione Peroxidase
Thioredoxin-Disulfide Reductase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gladyshev V N
Department of Biochemistry, University of Nebraska, Lincoln, NE 68588-0664, USA.
[email protected]
Stadtman T C
Hatfield D L
Jeang K T
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