Home LiteratureArticle Details
PMID: 99279 Published · ppublish English Journal Article

Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains.

Clinical and experimental immunology ·Vol. 32 ·No. 3 ·1978-06-00 ·Pages 429-34

Günther E, Odenthal H, Wechsler W

Abstract

The genetics of the inducibility of experimental allergic encephalomyelitis (EAE) was studied in ten inbred rat strains by injection of guinea pig spinal cord in complete Freund's adjuvant. LEW rats were highly susceptible and AS2, AVN, BDV and BN rats were poorly susceptible. Congenic strains which carried the major histocompatibility haplotype of the poorly susceptible strains on the genetic background of the susceptible LEW strain were only moderately susceptible. It is concluded that major histocompatibility-linked genes exert a strong influence on the susceptibility to EAE, but that genetic background genes are also involved.

MeSH Terms
Animals Encephalomyelitis, Autoimmune, Experimental/genetics,immunology Genes, MHC Class II Haploidy Major Histocompatibility Complex Rats Rats, Inbred Strains/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Günther E
Odenthal H
Wechsler W
References (11)
11 references, click to expand
  1. Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats.
    J Immunol. 1975 Aug;115(2):431-3 PMID: 1097514
  2. Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility.
    J Immunogenet. 1976 Aug;3(4):263-74 PMID: 1109134
  3. Allergic encephalomyelitis in the reputedly resistant Brown Norway strain of rats.
    J Immunol. 1975 Feb;114(2 Pt 1):597-601 PMID: 1120901
  4. Genetically controlled autologous immune complex glomerulonephritis in rats.
    J Immunol. 1975 Oct;115(4):895-7 PMID: 126258
  5. Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control.
    Eur J Immunol. 1977 Jun;7(6):348-51 PMID: 302206
  6. Genetic control of susceptibility to experimental allergic encephalomyelitis in rats.
    Science. 1973 Aug 31;181(4102):872-3 PMID: 4125048
  7. Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat.
    J Exp Med. 1973 Oct 1;138(4):775-83 PMID: 4126546
  8. Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells.
    Science. 1974 Nov 29;186(4166):839-41 PMID: 4143378
  9. The susceptibility of several inbred strains of rats to adjuvant-induced arthritis and experimental allergic encephalomyelitis.
    Z Immunitatsforsch Exp Klin Immunol. 1974 Jun;147(2):191-3 PMID: 4283010
  10. The immune response against myelin basic protein in two strains of rat with different genetic capacity to develop experimental allergic encephalomyelitis.
    J Exp Med. 1975 Jan 1;141(1):72-81 PMID: 46914
  11. Cellular events in the induction of experimental allergic encephalomyelitis in rats.
    J Exp Med. 1976 Sep 1;144(3):604-16 PMID: 60461
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1978-06-00
Pages
429-34
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1541337
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2