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PMID: 99365 Published · ppublish English Journal Article

Depression of contact sensitivity by enhancement of suppressor cell activity in Pseudomonas aeruginosa-injected mice.

Infection and immunity ·Vol. 21 ·No. 2 ·1978-08-00 ·Pages 354-9

Colizzi V, Garzelli C, Campa M, Falcone G

Abstract

Heat-killed Pseudomonas aeruginosa depresses contact sensitivity to oxazolone in C56BL/6 mice. The draining lymph nodes and spleens of mice exhibiting an impaired reactivity to oxazolone contain a cell population capable of depressing the response to oxazolone of recipients sensitized immediately before cell transfer. The suppressive activity of these cells appears to be antigen specific, since they do not affect the response to picryl chloride and because they do not arise in P. aeruginosa-injected but not oxazolone-sensitized mice. These suppressor cells occur in the draining lymph nodes and spleen at 3 and 4 days after sensitization, respectively, and have precursors sensitive to cyclophosphamide. It is concluded that P. aeruginosa depresses contact sensitivity to oxazolone by enhancing the suppressor cell activity of the regulatory cells which arise during conventional sensitization.

MeSH Terms
Animals Cyclophosphamide/pharmacology Female Hot Temperature Lymph Nodes/immunology Male Mice Mice, Inbred C57BL Oxazolone/immunology Picryl Chloride/immunology Pseudomonas aeruginosa/immunology Skin Tests Spleen/immunology T-Lymphocytes/immunology
Chemicals
Oxazolone Cyclophosphamide Picryl Chloride
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Colizzi V
Garzelli C
Campa M
Falcone G
References (20)
20 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.21.2.354-359.1978
Published
1978-08-00
Pages
354-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422002
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.21.2.354-359.1978 PMC Full Text View journal details
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