Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

British journal of clinical pharmacology ·Vol. 2 ·No. 6 ·1975-12-00 ·Pages 481-6

Burland WL, Duncan WA, Hesselbo T, Mills JG, Sharpe PC, Haggie SJ, Wyllie JH

Abstract

Cimetidine, a new H2-receptor antagonist, was safely administered to eighteen healthy man by the intravenous, intraduodenal or oral route. 2 When gastric secretion was maximally stimulated by either histamine or pentagastrin, the simultaneous administration of cimetidine produced marked inhibition of both acid and pepsin secretion. 3 Cimetidine was well absorbed by mouth and had a blood half-life of 2 hours. 4 Cimetidine was rapidly excreted via the kidneys and about 70% of the excreted material was unchanged drug. 5 Clinical evaluation of cimetidine in patients with peptic ulceration is recommended.

MeSH Terms

Administration, Oral Adult Duodenum Gastric Juice/metabolism Guanidines/pharmacology Half-Life Histamine/pharmacology Histamine H2 Antagonists/metabolism,pharmacology Humans Imidazoles/pharmacology Infusions, Parenteral Intubation, Gastrointestinal Male Middle Aged Pentagastrin/pharmacology Pepsin A/metabolism

Chemicals

Guanidines Histamine H2 Antagonists Imidazoles Histamine Pepsin A Pentagastrin

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Burland W L

Duncan W A

Hesselbo T

Mills J G

Sharpe P C

Haggie S J

Wyllie J H

References (10)

10 references, click to expand

Relief of duodenal ulcer sysmptons by oral metiamide.
Br Med J. 1975 May 10;2(5966):307-9 PMID: 236804
Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide.
Lancet. 1974 Apr 20;1(7860):693-4 PMID: 4132419
Inhibition of gastric secretion in man by metiamide: a new, orally active histamine H 2 -receptor antagonist.
Gut. 1973 May;14(5):424 PMID: 4146085
Metiamide--an orally active histamine H2-receptor antagonist.
Agents Actions. 1973 Oct;3(3):133-7 PMID: 4150324
Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer.
N Engl J Med. 1974 Aug 22;291(8):373-6 PMID: 4152590
Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.
Br Med J. 1974 Aug 31;3(5930):554-6 PMID: 4153330
Gastric response to metiamide.
Br Med J. 1974 May 11;2(5914):304-6 PMID: 4597122
Letter: Neutropenia associated with metiamide.
Lancet. 1975 Feb 15;1(7903):392-3 PMID: 46534
Letter: Metiamide in Zollinger-Ellison syndrome.
Lancet. 1975 Jan 4;1(7897):35-6 PMID: 46947
[The automatic determination of proteolytic activity of gastric juice].
Biol Gastroenterol (Paris). 1968;1:15-29 PMID: 4915505

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1975.tb00564.x

Published

1975-12-00

Pages

481-6

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1402643

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1975.tb00564.x PMC Full Text View journal details

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Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

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