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PMID: 998734 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Oxygen toxicity in the newborn. The effect of chronic continuous 100 percent oxygen exposure on the lungs of newborn mice.

The American journal of pathology ·Vol. 85 ·No. 3 ·1976-12-00 ·Pages 623-50

Bonikos DS, Bensch KG, Northway WH

Abstract

Continuous exposure of newborn mice of a single, highly inbred strain to 100% oxygen at normal atmospheric pressure for up to 6 weeks resulted in a progressive evolution of pulmonary changes which consisted of dense fibrous tissue deposition, chronic bronchitis and bronchiolitis, and emphysema. Survival of the experimental animals decreased with the duration of exposure, and it was 18% after the sixth week. While the pulmonary changes were evolving, lung growth was markedly inhibited in the experimental animals, whereas lung weight increased significantly. The present study indicates that in contrast to the adult mouse, survival of a substantial percentage of newborn mice for at least 6 weeks is possible, but it is associated with severe changes in pulmonary structure that doubtlessly lead to serious derangement of cardiopulmonary functions.

MeSH Terms
Animals Animals, Newborn Bronchi/drug effects Cell Division Epithelial Cells Epithelium/drug effects Lung/drug effects,growth & development,pathology Mice Mice, Inbred C57BL Mortality Necrosis Organ Size/drug effects Oxygen/adverse effects Pulmonary Alveoli/drug effects Pulmonary Fibrosis/chemically induced
Chemicals
Oxygen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bonikos D S
Bensch K G
Northway W H
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51 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1976-12-00
Pages
623-50
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032655
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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