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Protein Abundance of Hydrolytic Drug Metabolizing Enzymes in Different Tissue...

Subash(S),Ahire(D),Jones(RS),Ma(B),Tian(Y)... J Med Chem 2026-07-09

...APEH, CMBL, EPHX1/2, DPP4, and AADAC) across liver, intestine, and kidney tissues in humans, rats, mice, dogs, and monke...

A New APEH Cluster with Antioxidant Functions in the Antarctic Hemoglobinless...

Riccio(Alessia),Gogliettino(Marta),Palmier... PLoS One 2016-04-25

...APEH-1Dl) and the two APEHs from the red-blooded Antarctic fish Trematomus bernacchii (APEH-1(Tb) and APEH-2(Tb)). Homol...

In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes ...

Suzuki(Eiko),Nakai(Daisuke),Ikenaga(Hideno... Xenobiotica 2016-11-07

...APEH-immunodepleted cytosols lacked VPA-G hydrolase activity. Hepatic and renal APEH activity was negligible even at 24 ...

Discovery of a pyruvylated peptide-metabolizing enzyme using a fluorescent su...

Yoshioka(Kentaro),Komatsu(Toru),Hanaoka(Ke... Chem Commun (Camb) 2016-11-07

...APEH). Cells overexpressing APEH exhibited higher metabolic activity towards the probe, N-pyruvyl-leucyl-7-amido-4-methy...

Genetic and microbial factors modulating the ubiquitin proteasome system in i...

Cleynen(Isabelle),Vazeille(Emilie),Artieda... Gut 2014-09-09

...APEH and USP3. CYLD was the most significant gene with the intronically located rs12324931 the strongest associated SNP ...

A novel class of bifunctional acylpeptide hydrolases--potential role in the a...

Gogliettino(Marta),Riccio(Alessia),Balestr... FEBS J 2014-03-04

...APEH isoforms (APEH-1Tb and APEH-2Tb ) showed distinct temperature-kinetic behavior, with significant differences in the...

RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10...

Bergamo(Paolo),Cocca(Ennio),Palumbo(Rosann... PLoS One 2014-06-30

...APEH)/proteasome mediated pathways on pro-apoptotic activity of the isomer trans10,cis12 (t10,c12)-CLA. The basal activi...

Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mecha...

Sandomenico(A),Russo(A),Palmieri(G),Bergam... J Med Chem 2012-07-09

Acyl peptide hydrolase (APEH) catalyzes the removal of acetyl-amino acids from the N-terminus of peptides and cytoplasmi...

Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal d...

Palmieri(Gianna),Bergamo(Paolo),Luini(Albe... PLoS One 2012-02-13

...APEH. To find novel molecules able to down-regulate APEH activity, we screened a set of synthetic peptides, reproducing ...

Genetic evidence supporting the association of protease and protease inhibito...

Cleynen(Isabelle),Jüni(Peter),Bekkering(Ge... PLoS One 2012-03-01

...APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4), all located...

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