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Loss of Exocytosis Protein DOC2B is an Early Event in Type 1 Diabetes Develop...

Esparza(D),Oh(E),Hwang(J),Chatterjee Bhowm... bioRxiv 2026-01-06

...DOC2B) levels in circulating platelets as a marker of reduced β-cell function in early-onset T1D cohorts and nonobese di...

Revisiting the Platelet-β-Cell Axis: Insights into How Platelet-Derived Media...

Mustakin EJIFCC 2026-02-00

...DOC2B, a Ca2+-sensitive mediator of insulin vesicle fusion. Revisiting this axis clarifies how thromboinflammation and l...

Sensing and Communicating β-Cell Stress in the Context of T1D Etiology: New O...

Esparza(D),Jayasena(CS),Jovanovic-Talisman... Compr Physiol 2026-06-00

...DOC2B), a regulator of vesicle trafficking and membrane fusion, may contribute to these processes. Beyond its canonical ...

A case study of comprehensive association analysis and risk prediction of amy...

Xie(X),Jiao(X),Yang(K),Zhang(Q) Mol Biol Rep 2026-07-03

...DOC2B, which implicate ubiquitin-mediated protein degradation and intracellular vesicle trafficking in ALS pathogenesis....

Stress during pregnancy alters dendritic spine density and gene expression in...

Petit(Bérengère),Boissy(Alain),Zanella(Adr... Behav Brain Res 2016-03-28

...Doc2b), synaptic transmission (Nr1, Grin2A, Grin2B) and glucocorticoid receptor (Nr3C1) in hippocampus (HPC), prefrontal...

Direct quantitative detection of Doc2b-induced hemifusion in optically trappe...

Brouwer(Ineke),Giniatullina(Asiya),Laurens... Nat Commun 2016-05-24

...Doc2b. Contacting membranes are often coupled by a Doc2b-coated membrane stalk that resists forces up to 600 pN upon bea...

DOC2B and Munc13-1 differentially regulate neuronal network activity.

Lavi(Ayal),Sheinin(Anton),Shapira(Ronit),Z... Cereb Cortex 2015-04-13

...DOC2B's effects were mimicked by Strontium that elevates asynchronous release but not by a DOC2B mutant that enhances sp...

Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake.

Shimoda(Yoko),Okada(Shuichi),Yamada(Eijiro... Endocrinology 2015-12-15

...Doc2b binding to syntaxin 4. In addition, glucose-dependent insulinotropic polypeptide rescued the Tctex1d2 inhibition o...

Doc2b serves as a scaffolding platform for concurrent binding of multiple Mun...

Ramalingam(Latha),Lu(Jingping),Hudmon(Andy... Biochem J 2015-03-16

...Doc2b. Competition-based GST-Doc2b interaction assays revealed that Doc2b could simultaneously bind both Munc18-1 and Mu...

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glu...

Li(Jia),Cantley(James),Burchfield(James G)... Diabetologia 2015-07-06

...Doc2b (-/-) (Doc2bKO) and Doc2a (-/-)/Doc2b (-/-) (Doc2a/Doc2bKO) mice in vivo. In vitro GSIS and glucose uptake were as...

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