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Cholesterol-dependent lysosomal docking of mTORC1 mediated by TM6SF1.

Hong(S),Jia(L),Wang(R),Elghobashi-Meinhard... bioRxiv 2026-04-03

...LAMTOR1 to stabilize the Ragulator complex, and that disruption of cholesterol binding to TM6SF1 impairs this interactio...

ZDHHC9 palmitoylates LAMTOR1 to promote renal cell carcinoma malignant progre...

Liu(B),Hou(T),Liu(X),Liu(L),Ma(Z),Zhang(Y) Cell Death Dis 2026-03-19

The lysosomal regulator complex member LAMTOR1 serves as a crucial pivot that recruits the mechanistic target of rapamyc...

LAMTOR1 sorts APP to late endosomes via AP-3-mediated trafficking.

Zhou(C),Cao(W),Cong(R),Shan(C),Tian(Y),Xu(... J Mol Cell Biol 2026-08-26

...LAMTOR1, and its depletion caused accumulation of LAMTOR1 and APP within early endosomes, subsequently increasing Aβ. Th...

The SLC15A4-LAMTOR1 interaction licenses endolysosomal TLR-mediated mTOR sign...

Chiu(TY),Hall(PR),Lazar(DC),Kim(AS),Forli(... bioRxiv 2026-06-09

...LAMTOR1, a core scaffold subunit of the lysosomal Ragulator complex, and show that is required for coupling endolysosoma...

Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1...

Jang(Y),Ko(M),Lee(JY),Kim(JY),Lee(EW),Kwon... Autophagy 2025-12-00

...LAMTOR1 phenocopies the effects of ACA treatment, further supporting the role of LAMTOR1 as a target of ACA. These findi...

Regulation of Tetraspanin CD63 in Chronic Myeloid Leukemia (CML): Single-Cell...

Desterke(C),Bennaceur-Griscelli(A),Turhan(AG) Bioengineering (Basel) 2025-07-31

...LAMTOR1, CFL1, CD52, RAD52, MEIS1, and PDIA3, known to be implicated in hematopoietic malignancies. (4) Conclusion: Regu...

Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -...

Zada(Sahib),Noh(Hae Sook),Baek(Seon Mi),Ha... Cell Biol Int 2016-08-17

...LAMTOR1, that specifically regulates the ERK or mTOR pathway in lysosomes. p18/LAMTOR1 also interacts with p27(kip1) . H...

LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in a...

Panagopoulos(Ioannis),Gorunova(Ludmila),Bj... Cancer Genet 2016-03-04

...LAMTOR1-PRKCD and NUMA1-SFMBT1. RT-PCR together with Sanger sequencing verified the presence of fusion transcripts from ...

Identification of prostate cancer biomarkers in urinary exosomes.

Øverbye(Anders),Skotland(Tore),Koehler(Chr... Oncotarget 2016-08-02

...LAMTOR1 could be used to augment the sensitivity to 100%. Other prominent proteins were V-type proton ATPase 16 kDa prot...

Fusions involving protein kinase C and membrane-associated proteins in benign...

Płaszczyca(Anna),Nilsson(Jenny),Magnusson(... Int J Biochem Cell Biol 2015-03-31

...LAMTOR1) with genes encoding protein kinase C (PKC) isoforms PRKCB and PRKCD. PKCs are serine-threonine kinases that thr...

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