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Genomic Evaluation of the Genetic Structure and Analysis of Selective Evoluti...

Zhu(K),Ai(Z),Cai(Y),Li(Y),Cheng(Y),Zhang(Y... Biology (Basel) 2026-03-17

...LEPR). Conclusively, this study delineates a comprehensive genomic landscape of the Xupu goose, providing a robust found...

Clinical Improvements with Setmelanotide in a 2-Year-Old Patient with Hyperph...

Pons(MR),Gutierrez Vilar(M),Rodriguez(AP),... Obes Facts 2026-03-27

...LEPR) deficiency, but there are limited clinical data on treatment outcomes in very young children. This case report des...

Preeclampsia Genomic Susceptibility Factors in Populations of African Ancestr...

Katsukunya(JN),Davidson(B),Mnika(K),Soko(N... Int J Mol Sci 2026-03-12

...LEPR and TNF-α; OR (95% CI): 2.07 (1.68-2.54); I2: 42.2%, p = 0.04; GRADE: low certainty) and cellular homeostasis genes...

Subchondral H-type blood vessel formation aggravates articular cartilage dege...

Yu(C),Zhao(X),Luo(S),Qin(J),Li(J) Front Med (Lausanne) None

...LEPR knockout mice, the correlation between abnormal subchondral bone metabolism and LEP, LEPR, and H-type vessel format...

Convergence and Parallelism of Phenotypic and Molecular Genetic Variability i...

Kosovsky(GY),Glazko(TT) Dokl Biol Sci 2026-02-00

...LEPR) in humans, rabbits, cattle, and house mice. A higher preservation of ancient variants was detected in MSTN-flankin...

Medullary cavity expansion is mediated by distinct cell populations during fe...

Sumiya(E),Saeki(K),Nakano(K),Kikutake(C),K... Nat Commun 2026-04-14

...LepR+ bone marrow stromal cells (BMSCs). During fracture repair, FABP5+ septoclasts and LepR+ BMSCs are redeployed withi...

Leptin Receptor Fibroblasts Are Preferential Contributors to Cardiac Fibrosis...

Larcher(V),Fischer(A),Zhang(L),Almolla(O),... Circ Res 2026-05-22

...LepR (leptin receptor). LepR+ CFs emerged neonatally, occupied a defined niche in the coronary adventitia, exhibited enh...

Transcriptomic Insights into Lobular Breast Cancer Biology and Patient Outcom...

Desmedt(C),Nguyen(HL),Richard(F),Linn(S),M... Clin Cancer Res 2026-08-03

...LEPR), whereas IBC-NST favored lipid synthesis (FASN). Decreased ER signaling, increased PI3K/Akt signaling, and differe...

Early-Onset Monogenic Obesity due to Leptin Receptor Deficiency: Fatal Outcom...

Tercan(U),Kandemir(T),Kardelen(AD),Bas Iki... Horm Res Paediatr 2026-04-18

Early-onset monogenic obesity due to leptin receptor (LEPR) deficiency is characterized by severe hyperphagia, rapid wei...

Systemic and Local Adiposity in the Bone Marrow Microenvironment Associated W...

Matos(A),Cawthorn(WP),Marinho-Dias(J),Rama... Int J Cancer 2026-08-01

...LEPR and IGFBP3 in adipocytes, while stromal cells overexpressed IGF-axis receptors. In in vitro studies, human recombin...

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