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Phytogalactolipids triggered oxidative stress to inhibit drug-resistant color...

Ho(YF),Tsai(YH),Jian(TY),Lin(HH),Shyur(LF)... Phytomedicine 2026-04-00

...LPAR2, inhibited the LPAR2 signaling pathways, and induced IFI6-mediated ROS accumulation to combat drug-resistant CRC.

Development of an Extended-release Formulation of Radioprotectin-1 for Mitiga...

Norman(DD),Lee(SC),Shin(Y),Ibrahim(MM),Jab... Radiat Res 2026-01-27

...LPAR2) is one mechanism by which radiation damage can be mitigated. Our laboratory has previously developed 5-chloro-2-(...

Anticancer drug-treated fibroblasts modulate colon cancer cell behavior throu...

Yamamoto(M),Yashiro(N),Kusumoto(Y),Nagano(... Acta Histochem 2026-06-00

...LPAR2 levels, compared with co-culture with untreated fibroblasts (n = 3 independent experiments). Under these condition...

Multi-omics identifies an epithelial-B cell cross-talk that drives functional...

Li(X),Zhang(Y),Ji(D),Li(L),Deng(Y),Wang(H)... Cell Signal 2026-05-00

...LPAR2 signaling modulates B cell activation and cytotoxic function, thereby facilitating metastatic progression. We deve...

Cftr nominates a novel therapeutic target for Alzheimer's disease: Evidence f...

Li(HR),Shi(JZ),Zhang(MJ),Yun(LY),Zhou(YF),... Neuropharmacology 2026-03-15

...Lpar2, Pnp2, Cftr, and Sstr3. PCR-based validation in both in vivo and in vitro models confirmed Cftr as the most promis...

Multi-omics analysis the effects of Dhx37 deficiency on testis development an...

Jiang(Y),Chen(J),Ren(Y),Peng(W),Shen(W),Zh... Cell Death Discov 2026-01-14

...Lpar2, PI3KR2, PI3KR5) and upregulation of the P53 pathway, culminating in apoptosis. As a result, Dhx37 deficiency impa...

Enhancement of malignant potency through lysophosphatidic acid (LPA) receptor...

Nagano(S),Takai(M),Yashiro(N),Shimomura(N)... Cytotechnology 2026-04-00

...LPAR2 and LPAR3 expression in PANC-M10 cells. Although cell proliferation in response to LPA treatment in 1% O2 culture ...

Construction of an actin cytoskeleton-related gene signature for predicting p...

Li(M),Li(J),Li(Z),Liu(G),Zhou(Y),Meng(M),C... Transl Cancer Res 2026-04-30

...LPAR2-were identified and used to develop a robust prognostic signature. This signature showed significant correlations ...

Integrated analysis of cell-in-cell related genes and immune microenvironment...

Zhao(L),Zhou(Y),Sun(J),Liu(S),Liu(W),Li(A) Front Cell Dev Biol None

...LPAR2 and GZMB and the downregulation of IL-10 in the TAC model. CIC-related genes possess significant diagnostic value ...

Insights into the binding mechanism and structural requirements of LPAR2 anta...

Zhang(Y),Xu(G),Wu(P) J Comput Aided Mol Des 2026-05-04

Lysophosphatidic acid receptor 2 (LPAR2), a G protein-coupled receptor, has been implicated in the progression of fibros...

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