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Diphenyl Diselenide and Temozolomide: Downregulation of Inflammatory, Redox, ...

Rieder(GS),Rieder(AS),da Silva(LDS),Ajayi(... Biol Trace Elem Res 2026-07-00

...NEK1, NEK2, and SNAIL1. The results indicate that DPDS, particularly in combination with TMZ, attenuated pro-inflammator...

Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, p...

Georgiadou(P),Erkaya(B),Niwa-Kawakita(M),O... FEBS J 2026-03-10

...Nek1 (Nek1t) is aggregation-prone, particularly in alpha-motoneurons (αMNs), and drives canonical ALS symptoms when bi-a...

NEK1 Promotes Ovarian Cancer Progression via p53 Suppression While Enhancing ...

Song(H),Wang(X),Yang(A),Ren(X),Zhou(X),Qiu... Curr Issues Mol Biol 2026-05-07

...NEK1 in ovarian cancer. Our findings demonstrate that NEK1 promotes tumor progression both in vitro and in vivo. Mechani...

DNA methylation signatures in skeletal muscle associated with physical functi...

Wen(X),Chen(M),Miao(G),Wu(C),Picca(A),Tama... Geroscience 2026-08-08

...NEK1 and SHANK1 (neurological function). Enrichment analysis revealed that 6MWT-associated genes relate to nervous and s...

Genetic variants among patients with motor neuron disease in Lithuania - a re...

Naktinytė(E),Vilimienė(R),Valančius(D),Bar... Neurogenetics 2026-07-31

...NEK1 genes and likely pathogenic variants in the FUS. The most common finding was C9orf72 hexanucleotide repeat expansio...

Nuclear condensates formed by truncated mutant NEK1s impede ribosomal RNA bio...

Wang(Y),Hu(W),Huang(R),Wu(F),Su(H),Zang(J)... Nat Commun 2026-07-13

...NEK1), a serine/threonine kinase, is a risk variant for amyotrophic lateral sclerosis (ALS). While the full-length NEK1 ...

NIMA-related kinase family at the nexus of skeletal development and congenita...

Zhao(Y),Zheng(Y),Chen(Q),Yang(Y),Zhang(L) Front Genet None

...NEK1 and NEK9, cause skeletal and joint developmental abnormalities. This review synthesizes clinical, genetic, and func...

PML as a neuroprotective guardian: Leveraging nuclear protein quality control...

Stark(T),Müller(S) FEBS J 2026-06-19

...NEK1 truncation mutant is recruited to PML NBs, where it likely undergoes SUMOylation and ubiquitylation. In mice, PML l...

Behavioral variant frontotemporal dementia associated with a NEK1 missense va...

Totuk(O),Sahin(S) Neurogenetics 2026-06-23

NEK1 variants are recognized genetic contributors to amyotrophic lateral sclerosis (ALS) and have occasionally been repo...

A rare missense variant impacting NEK1 kinase function is associated with ALS...

Brenner(D),Ponomarenko(A),Petrut(I),Beyrle... Acta Neuropathol Commun 2026-06-25

...NEK1 are a known cause of amyotrophic lateral sclerosis (ALS). NEK1 encodes the pleiotropic serine/threonine kinase NIMA...

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