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Tumoral switch in NUMB splicing changes essential transcription pathways and ...

García-Heredia(JM),Ortega-Campos(SM),Carne... Genome Biol 2026-06-24

...NUMBL, a NUMB homolog, displays expression patterns similar to p65. We further identify two transcriptional clusters: on...

Internalized components of membrane attack complexes disrupt proteostasis and...

Song(G),Ma(Z),Fan(M),He(L),Lan(Y),Li(W),Ji... Nat Commun 2026-07-17

...NUMBL as a Rab35 effector that directly binds surface-bound C9 to promote C9 internalization and entry into the endolyso...

Internalized Components of Membrane Attack Complexes Disrupt Proteostasis and...

Song(G),Ma(Z),Fan(M),He(L),Lan(Y),Li(W),Ji... bioRxiv 2026-07-03

...NUMBL as a Rab35 effector that directly binds surface-bound C9 to promote C9 internalization and entry into the endolyso...

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

Loukola(Anu),Buchwald(Jadwiga),Gupta(Richa... PLoS Genet 2016-04-29

...NUMBL. Conditional analyses revealed three independent signals on 19q13, all located within or in the immediate vicinity...

Regulation of vascular endothelial growth factor receptor function in angioge...

van Lessen(Max),Nakayama(Masanori),Kato(Ka... Arterioscler Thromb Vasc Bi... 2015-10-14

...Numbl genes in the postnatal endothelium led to impaired vessel growth, reduced endothelial proliferation and sprouting,...

Identification of genomic signatures in circulating tumor cells from breast c...

Kanwar(Nisha),Hu(Pingzhao),Bedard(Philippe... Int J Cancer 2015-07-31

...NUMBL). Furthermore, a region harboring the ERBB2 gene was gained in a majority of patients. Regions 20q13 and 15q24 wer...

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signa...

Swarnkar(Gaurav),Karuppaiah(Kannan),Mbalav... Proc Natl Acad Sci U S A 2015-04-23

...NUMBL) levels. Accordingly, forced expression of Numbl abrogated osteoclastogenesis whereas its deletion partially resto...

NumbL is essential for Xenopus primary neurogenesis.

Nieber(Frank),Hedderich(Marie),Jahn(Olaf),... BMC Dev Biol 2014-06-18

...Numblike (NumbL) during Xenopus development and characterize the function of NumbL during primary neurogenesis. NumbL, i...

Numb family proteins are essential for cardiac morphogenesis and progenitor d...

Zhao(Chen),Guo(Hua),Li(Jingjing),Myint(Tho... Development 2014-02-25

Numb family proteins (NFPs), including Numb and numb-like (Numbl), are cell fate determinants for multiple progenitor ce...

Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regula...

Bogdanović(Ozren),Delfino-Machín(Mariana),... Dev Cell 2013-02-07

...Numbl via an integrin-like NPxF motif, Opo antagonizes Numb/Numbl function and acts as a negative regulator of integrin ...

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