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Exploring spinal degenerative diseases therapy targets through druggability g...

Qin(H),Hao(M),Wang(Z),Zhang(J),Xie(M),Diao... Naunyn Schmiedebergs Arch P... 2026-06-00

...PIK3C2A was linked to increased risk of spinal canal stenosis (OR: 1.086, 95% CI: 1.056-1.117, PFDR = 9.01 × 10-9). In c...

Identification and experimental validation of aging-related biomarkers in int...

Zhang(F),Yuan(L),Ding(H),Lou(Z),Li(X) Sci Rep 2026-04-09

...PIK3C2A exhibited consistent expression trends across IHC, RT-qPCR, WB assays and the two datasets. BTG3 and PIK3C2A may...

Oculoskeletodental syndrome: expansion and review of the clinical and molecul...

Al-Rashdi(M),Al-Hadabi(A),Mameesh(M),Ganes... Clin Dysmorphol 2026-07-01

...PIK3C2A plays a crucial role in membrane trafficking and various intracellular signaling pathways by synthesizing lipid ...

Construction and Validation of an Early Diagnosis Model for Atherosclerosis B...

Wang(X),Hou(X),Yu(H),Wang(S),Yang(X) Curr Med Chem 2026-07-29

...PIK3C2A), achieving AUCs of 0.730 and 0.758 and supporting the model's clinical relevance. This study demonstrates that ...

circNCX1-nanogel mitigates radiation-induced heart disease.

Cao(S),Wang(X),Bai(X),Pang(C),Wang(J),Wang... Biomaterials 2026-08-10

...PIK3C2A, thereby augmenting PI3K/AKT/mTOR signaling and limiting radiation-induced apoptosis. Building upon this observa...

Purpurin Rescues Contrast-Induced Acute Rat Kidney Injury via Inducing Autoph...

He(K),Sun(X),Pan(X),Yang(X),Wang(Q),Liao(K... Pharmaceuticals (Basel) 2026-01-08

...Pik3c2a, Esr1, Aktip, HSP90AA1, Bcl2, Caspase3, and SRC in the CIAKI group of GSE189881 were significantly differentiall...

Novel ocular feature in oculoskeletodental syndrome: high axial myopia and me...

Pawar(N),R(M),J(A),A(F),Lakshmi(S),Kk(S) Ophthalmic Genet 2026-08-00

Oculoskeletodental syndrome (OCSKD) is a rare autosomal recessive ciliopathy caused by PIK3C2A loss-of-function variants...

Structural patterns and transcriptional effects of integrated Epstein-Barr Vi...

Kardan(Z),Kadam(A),Chai(AWY),Cheong(SC),Lo... Virol J 2026-05-12

...PIK3C2A. Notably, EBV-human fusion events were prevalent in EBV-associated NPCs, including intriguing fusion transcripts...

Novel role of the class II α-isoform of phosphatidylinositol 3-kinase in hepa...

Chen(J),Ren(LX),Ma(Y),Cheng(WH),Liu(T) Cancer Cell Int 2026-06-22

...PIK3C2A was frequently down-regulated in human HCC cells and tissues. Low PIK3C2A expression correlated with elevated LR...

tsRNA-3025a Impairs Mitochondrial Function and Autophagy to Inhibit Myocardia...

Feng(Z),Li(X),Zhou(A),Zhang(H),Tang(K),Yan... J Cardiovasc Dev Dis 2026-06-12

...PIK3C2A, thereby suppressing autophagosome formation and impairing protective autophagic flux during reperfusion. In con...

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