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Tumor microenvironment and signaling pathways in melanoma brain metastasis.

Rosell(R),González-Cao(M),Olmo-González(D)... Ann Transl Med 2026-08-31

...TCTN1) and carnitine palmitoyltransferase 1A (CPT1A) enhances fatty acid oxidation and promotes melanoma metastasis. The...

Genetic Identification of Potential Drug Targets for Dental Caries: A Mendeli...

Bi(J),Liu(A),Zhang(N),Chen(Y),Liu(C),Zhu(Y... Health Sci Rep 2026-05-00

...TCTN1. These genes were analyzed to explore their roles in dental caries. Molecular docking studies identified paclitaxe...

Tectonic‑1 contributes to the growth and migration of prostate cancer cells i...

Wang(Zhijun),Gao(Yi),Liu(Yushan),Chen(Jie)... Int J Mol Med 2016-06-20

...TCTN1 was widely expressed in several human prostate cancer cell lines. Knockdown of the TCTN1 gene by RNA interference ...

Cognitive rehabilitation in a child with Joubert Syndrome: Developmental tren...

Gagliardi(Chiara),Brenna(Viola),Romaniello... Res Dev Disabil 2016-08-31

...TCTN1 gene and affected by Joubert Syndrome (JS). JS is a congenital cerebellar ataxia characterized by "the molar tooth...

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Sup...

Yee(Laura E),Garcia-Gonzalo(Francesc R),Bo... PLoS Genet 2016-06-03

...Tctn1 and either Nphp1 or Nphp4 exacerbated defects in ciliogenesis and cilia-associated developmental signaling, as did...

Lentivirus-Mediated Knockdown of TCTN1 Inhibits Glioma Cell Proliferation.

Li(Jinsong),Wang(Handong),Hang(Chunhua),Fa... Appl Biochem Biotechnol 2016-02-11

...TCTN1 is extensively expressed in human glioma cell lines. To clarify the role of TCTN1 in glioma, we employed lentiviru...

Tectonic 1 accelerates gastric cancer cell proliferation and cell cycle progr...

Wang(Xinbao),Yu(Qiming),Zhang(Yingli),Ling... Mol Med Rep 2016-06-27

...TCTN1) was identified as one regulator of the Hh pathway. In the present study, the biological role of TCTN1 was examine...

Tectonic 1 Is a Key Regulator of Cell Proliferation in Pancreatic Cancer.

Zhao(Shiyong),Chen(Xuedong),Wan(Ming),Jian... Cancer Biother Radiopharm 2016-10-25

...TCTN1 expression in PANC-1 pancreatic cancer cells. Knockdown of TCTN1 expression potently inhibited cell viability and ...

Tectonic gene mutations in patients with Joubert syndrome.

Huppke(Peter),Wegener(Eike),Böhrer-Rabel(H... Eur J Hum Genet 2016-01-06

So far very few patients with sequence variants in the closely related tectonic genes TCTN1-3 have been described. By mu...

Lentivirus-Mediated knockdown of tectonic family member 1 inhibits medullobla...

Jing(Junjie),Wang(Chengfeng),Liang(Qinchua... Int J Clin Exp Med 2015-11-09

...TCTN1 in medulloblastoma cell line Daoy. The results showed that knockdown of TCTN1 inhibited cell proliferation and col...

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