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Blocking sp1 transcription factor broadly inhibits extracellular matrix gene ...

Verrecchia(F),Rossert(J),Mauviel(A) J Invest Dermatol 2001-07-05

...COL5A2, COL7A1, TIMP-1, and decorin) promoter/reporter constructs demonstrated that anti-sense Sp1-induced reduction of ...

Colorectal carcinogenesis is associated with stromal expression of COL11A1 an...

Fischer(H),Stenling(R),Rubio(C),Lindblom(A... Carcinogenesis 2001-06-21

...COL5A2 was not expressed in normal colon but was co-expressed with COL11A1 in the tumours. Our results suggest that stro...

Association of markers for TGFbeta3, TGFbeta2 and TIMP1 with systemic sclerosis.

Susol(E),Rands(A L),Herrick(A),McHugh(N),B... Rheumatology (Oxford) 2001-02-01

...COL5A2 were genotyped and allele frequency distributions compared in 191 patients and 196 controls. As TIMP1 maps to the...

Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts usi...

Verrecchia(F),Chu(M L),Mauviel(A) J Biol Chem 2001-07-05

...COL5A2, but not COL6A2, as novel Smad targets. Together, these results represent a significant step toward the identific...

Stickler syndrome: further mutations in COL11A1 and evidence for additional l...

Martin(S),Richards(A J),Yates(J R),Scott(J... Eur J Hum Genet 2000-01-20

...COL5A2, COL11A1 and COL11A2. Two families were linked to COL11A1 and sequencing identified mutations resulting in shorte...

Cooperative interactions between PBX, PREP, and HOX proteins modulate the act...

Penkov(D),Tanaka(S),Di Rocco(G),Berthelsen... J Biol Chem 2000-07-11

...COL5A2-positive cells, the FPB complex from COL5A2-negative cells contains PBX2 and PREP1 but lacks PBX1. However, PBX1 ...

B-Myb represses trans-activation of the Col5A2 collagen promoter indirectly v...

Kypreos(K E),Marhamati(D J),Sonenshein(G E... Matrix Biol 1999-10-26

...Col5A2, encoding the (alpha2 chain of type V collagen. Ectopic expression of B-Myb decreased alpha 2(V) promoter activit...

A single base mutation in COL5A2 causes Ehlers-Danlos syndrome type II.

Richards(A J),Martin(S),Nicholls(A C),Harr... J Med Genet 1999-01-05

...COL5A2 as the disease locus. The entire open reading frame of the COL5A2 cDNA was directly sequenced and a single base m...

Mutations of the alpha2(V) chain of type V collagen impair matrix assembly an...

Michalickova(K),Susic(M),Willing(M C),Wens... Hum Mol Genet 1998-03-17

...COL5A2 gene, which encodes the alpha2(V) chain of type V collagen, in two unrelated patients with the severe type I form...

Cell-specific regulation of alpha1(III) and alpha2(V) collagen by TGF-beta1 i...

Bertelli(R),Valenti(F),Oleggini(R),Caridi(... Nephrol Dial Transplant 1998-05-27

...COL5A2 mRNA (+500%) with a stimulatory effect (+100%) on a 1177 bp fragment of COL5A2 promoter. In this case a relevant ...

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