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Low-grade serous carcinoma metastasizing to the chest wall and incidental Mül...

Miyama(Y),Omori(H),Uranishi(K),Hirasaki(M)... Gynecol Oncol Rep 2026-08-00

...KRAS hotspot mutations. This case highlights the potential for the very late malignant progression of ovarian SBTs and t...

Application Value of Multi-Gene Testing in the Evaluation of Benign and Malig...

Zhang(M),Xie(L),Xu(F),Liu(L),Wang(Y),Jiang... Iran J Biotechnol 2026-07-00

...KRAS, NRAS, TP53, TERT, RET, NTRK1, NTRK3, PAX8, THADA. Gene mutations were identified in 226 nodules (226/247; 91.5%), ...

Computational strategies for allosteric drug discovery: from cryptic pocket d...

Mukhopadhyay(S),Chakrabarty(S) Chem Commun (Camb) 2026-08-04

...KRAS, which turned a long-"undruggable" oncoprotein into a clinically validated target, exemplifies this promise. Yet al...

First report of dual KRAS Y96C/Y96S resistance mutations detected by liquid b...

Wang(Z),Hong(D),Zhang(L),Qin(Y),Guo(Z),Huo... Oncologist 2026-07-08

...KRAS G12C-mutated mCRC who progressed after 9.3 months of sequential KRAS G12C inhibitor monotherapy. Comparative molecu...

Precision Medicine in Pancreatic Cancer: Targeting KRAS and Beyond.

Schürmann(H),Park(W),O'Kane(GM),Sciortino(... Target Oncol 2026-07-00

...KRAS-mutant and KRAS wild-type disease. We will outline how our expanding biological insights into pancreatic cancer cou...

First-Line Immunotherapy Versus Chemotherapy in MSI-H/dMMR Metastatic Colorec...

Ben Kridis(W),Khanfir(A) J Gastrointest Cancer 2026-07-20

...KRAS/NRAS mutation status, and primary tumor location. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) we...

A distinctive PDZ:β-hairpin interaction mediates AFDN complex with SCRIB and ...

Jo(CH),Strakhova(R),Goudreault(M),Bernal A... Biochem J 2026-08-05

...KRAS oncoprotein. The identified β-hairpin motif is highly conserved across deuterostomes but absent from most invertebr...

Streamlined Scalable Synthesis of 4-Bromo-6-chloro-5-iodo-1-(tetrahydro-2H-py...

Zhu(X),Xue(S),Wang(W),Zhang(X),Cui(Z),Chen... J Org Chem 2026-07-31

...KRAS inhibitor building block 4-bromo-6-chloro-5-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole. The route comprises six ...

LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer t...

Wang(Z),Huang(Q),Zhao(J),Lyu(Z),Ju(F),You(... Cell Death Dis 2026-07-20

...KRAS-subtype cells (BxPC-3, TBO368). Integrated analyses revealed mitochondrial dysfunction and defective mitophagy as h...

Prognostic Relevance of Surgical Margins According to KRAS and BRAF Status in...

Ferrari(C),Molina(V),D'Ambrosio(GM),Famula... Ann Surg Oncol 2026-07-20

...KRAS and BRAF mutations, has emerged as a key determinant of outcomes. This study investigated whether mutational status...

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