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TP53 BRCA1 CRISPR single-cell cancer

Nakai(N),Obayashi(M),Nagasaki(M),Sato(Y),F... Life Sci 2001-02-08

...PDK1, 2, and 4 were detected in all the regions examined. The level of PDK2 mRNA was the most abundant among the isoenzy...

Belham(C),Comb(M J),Avruch(J) Curr Biol 2001-12-04

...PDK1, whereas the kinase responsible for the phosphorylation of the latter site is not known.,The major protein kinase t...

Richards(S A),Dreisbach(V C),Murphy(L O),B... Mol Cell Biol 2001-12-04

...PDK1). Previous work has shown that upon mitogen stimulation, RSK accumulates in the nucleus. Here we show that prior to...

Kolobova(E),Tuganova(A),Boulatnikov(I),Pop... Biochem J 2001-09-20

...PDK1, PDK2, PDK3 and PDK4) differ in their abilities to phosphorylate the enzyme. PDK1 can phosphorylate all three sites...

Korotchkina(L G),Patel(M S) J Biol Chem 2001-12-04

...PDK1 > PDK3; for site 2, PDK3 > PDK4 > PDK2 > PDK1). Site 3 was phosphorylated by PDK1 only. The maximum activation by d...

Wang(X),Li(W),Williams(M),Terada(N),Alessi... EMBO J 2001-10-25

...PDK1) has been genetically knocked out. This is not due to loss of mTOR function since phosphorylation of another target...

Biondi(R M),Kieloch(A),Currie(R A),Deak(M)... EMBO J 2001-10-25

...PDK1. In contrast, the PIF-binding pocket of PDK1 is not required for the phosphorylation of PKBalpha by PDK1. The PIF-b...

Oriente(F),Formisano(P),Miele(C),Fiory(F),... J Biol Chem 2001-12-04

...PDK1 (a phosphatidylinositol trisphosphate-dependent kinase) and Akt/protein kinase B (PKB) activation by insulin showed...

Park(J),Hill(M M),Hess(D),Brazil(D P),Hofs... J Biol Chem 2001-12-04

...PDK1 activity are poorly understood. PDK1 has been reported to be constitutively active in resting cells and not further...

Clyde(D),Bownes(M) J Endocrinol 2001-10-04

...PDK1), and also has homologues in S. cerevisiae, S. pombe, C. elegans, A. thaliana, mouse, and sheep. Where its function...

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