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TP53 BRCA1 CRISPR single-cell cancer

Kroner(C),Eybrechts(K),Akkerman(J W) J Biol Chem 2000-10-13

...PDK1) and Ser(473) (via a not yet identified PDK2). In addition, alpha-thrombin activates a PI-3K-independent pathway in...

Hu(Y),Qiao(L),Wang(S),Rong(S B),Meuillet(E... J Med Chem 2000-09-08

...PDK1 and 2), which phosphorylates and activates Akt. Akt inhibits apoptosis by phosphorylating Bad, thus promoting its b...

Carver(D J),Aman(M J),Ravichandran(K S) Blood 2000-09-07

...PDK1, also require PIP3 for activation. In this report, we addressed whether SHIP inhibits Akt directly at the level of ...

Balendran(A),Hare(G R),Kieloch(A),Williams... FEBS Lett 2000-12-22

...PDK1). In this study, we demonstrate that in embryonic stem (ES) cells lacking PDK1 (PDK1-/- cells), the intracellular l...

Mann(W R),Dragland(C J),Vinluan(C C),Vedan... Biochim Biophys Acta 2000-10-30

...PDK1 and PDK2. During these studies, PDC was shown to be directly inhibited by a novel mechanism; the addition of supple...

Grillo(S),Grémeaux(T),Casamayor(A),Alessi(... Eur J Biochem 2000-12-28

...PDK1. In unstimulated adipocytes, overexpressed PDK1 was mostly cytosolic with a low amount associated to membranes. Per...

Sugden(M C),Lall(H S),Harris(R A),Holness(... J Endocrinol 2000-12-15

...PDK1-4) regulate glucose oxidation through inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC). Immun...

Corbit(K C),Soh(J W),Yoshida(K),Eves(E M),... Mol Cell Biol 2000-08-10

...PDK1 in H19-7 cells. PKCzeta, like PKCdelta, acts upstream of MEK, and PKCzeta can potentiate Raf-1 activation by EGF. I...

Filippa(N),Sable(C L),Hemmings(B A),Van Ob... Mol Cell Biol 2000-08-10

...PDK1) in protein kinase B (PKB) activation and translocation to the cell surface. Wild-type and PDK1 mutants were transf...

Frödin(M),Jensen(C J),Merienne(K),Gammelto... EMBO J 2000-08-07

...PDK1. Treatment of cells with growth factor induced recruitment of PDK1 to the Ser386-phosphorylated hydrophobic motif a...

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