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METTL14 deficiency impairs chondrogenic differentiation via m6A-dependent TRA...

Zhang(Q),Naren(G),Zhang(J),Yang(P),Deng(X)... Int Immunopharmacol 2026-04-15

...COL2A1, SOX9, TGF-β1, and PTHrP, while pharmacological activation via quercetin restored METTL14 expression and ameliora...

Retinal detachment in patients with Sticklers syndrome: A comprehensive analy...

Bleeker(AJ),Sullivan(NAT),Brouwer(AH),de K... JPRAS Open 2026-05-00

...COL2A1 pathogenic variant, and degree of myopia. The primary outcome was occurrence of a retinal event, defined as a ret...

Aberrant miR-410-5p expression occurs in human lumbar intervertebral disk deg...

Wang(F),Zhang(J),Zhao(L),Ji(Y) Nucleosides Nucleotides Nuc... 2026-03-02

...COL2A1, ACAN), while AIFM1 overexpression reversed these effects. MiR-410-5p is downregulated in IDD and serves as a pot...

Extracellular Matrix Stiffness as a Key Molecular Event in Early Osteoarthrit...

Huang(K),Cai(H),Hong(Y),Wu(L),Bao(J),Jiang... Am J Sports Med 2026-03-00

...COL2A1 and ACAN reduced to 0.0146 ± 0.0008 versus 0.0151 ± 0.0013 (P < .0001), respectively, and 0.0347 ± 0.0041 versus ...

Isoquercitrin attenuates osteoarthritis progression by targeting P53-mediated...

Li(H),Chen(G),Ma(C),Hu(Y),Zhou(P),Zhou(S),... J Nutr Biochem 2026-07-00

...COL2A1 and ACAN, while downregulating MMP13 and ADAMTS5. Concurrently, ISO reduced intracellular levels of reactive oxyg...

miR-145-5p combined with miR-140-5p regulates the differentiation of bone mar...

Chen(X),Cao(K),Feng(H) J Orthop Surg Res 2026-02-11

...COL2A1 and Aggrecan, alongside decreased miR-145-5p levels, reduced ROS and enhanced SOD activity. Mechanistically, SOX9...

Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 m...

Nevarez(L),Ismaili(TK),Zieba(J),Martin(J),... JCI Insight 2026-01-23

...Col2a1-Cre resulted in a skeletal dysplasia affecting the long bones, spine, and craniofacial skeletal elements, consist...

Chondrogenic Potential of Periosteum-Derived Cells.

Hochmann(S),Brachtl(G),Poupardin(R),Hoog(A... Transfus Med Hemother 2026-05-28

...COL2A1 expression in appendicular-derived PDCs, indicating superior intrinsic chondrogenic potential. Culturing jaw-deri...

The role of the HB-EGF-regulated EGFR-mitophagy axis in maintaining cartilage...

Wang(J),Mo(C),Wang(Q),Qin(J),Li(Y),Peng(W) J Mol Histol 2026-08-04

...Col2a1). Further analysis revealed that HB-EGF enhanced mitophagy, as indicated by increased levels of Pink1, Parkin, an...

Integrating network toxicology, molecular docking and experimental validation...

Feng(R),Tuerhong(X),Cai(Y),Aihaiti(Y) Exp Gerontol 2026-09-00

...COL2A1, phenocopying IL-1β-induced cartilage degradation. Immunohistochemistry further validated elevated MMP9 in damage...

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