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IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.

Jung(Mi-Yeon),Smrž(Daniel),Desai(Avanti),Ban… J Immunol 2013-03-14

...Hck. These findings suggest that IL-33 may play a protective, rather than a causative, role in MC activation under chron...

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef a…

Emert-Sedlak(Lori A),Narute(Purushottam),Shu… Chem Biol 2013-07-09

...Hck, a Src family member and Nef effector protein. Using this assay, we screened a large, diverse chemical library and i...

Characterization of vitamin C-induced cell sheets formed from primary and immor…

Grobe(Gesa Maria),Reichl(Stephan) Cells Tissues Organs 2013-09-23

...HCK cells) to synthesize their own extracellular matrix induced by vitamin C supplementation. Therefore, the amount of c...

Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in …

Fumagalli(Laura),Campa(Carlo C),Germena(Giul… J Immunol 2013-05-21

...Hck, Fgr, and Lyn. Our studies show that PI3Kγ is indispensable for the early, fMLF-induced ROS generation and AKT and E...

The SRC family tyrosine kinase HCK and the ETS family transcription factors SPI…

Asai(Tsuneaki),Morrison(Sherie L) J Biol Chem 2013-06-07

...HCK regulates apical-to-basolateral transcytosis of non-opsonized and SIgA-opsonized particles. We also show that, in cu...

Hck contributes to bone homeostasis by controlling the recruitment of osteoclas…

Vérollet(Christel),Gallois(Anne),Dacquin(Rom… FASEB J 2013-11-12

...hck(-/-) mice, we examined the individual contribution of Hck in bone homeostasis. Compared to wt mice, hck(-/-) mice ex...

A study of the mechanism of the chaperone-like function of an scFv of human cre…

Feng(Jianyu),Guo(Hong),Li(Sen),Lu(Tun) PLoS One 2013-12-09

...HCK) by the homology modeling method. Epitopes of human creatine kinase were predicted by computer and then the binding ...

Individual Src-family tyrosine kinases direct the degradation or protection of …

O'Reilly(Linda P),Zhang(Xiong),Smithgall(Tho… Cell Signal 2013-09-17

...Hck, c-Src and c-Yes. Co-expression of Tim with Fyn or Hck was followed by ubiquitylation and subsequent degradation in ...

Salmonella downregulates Nod-like receptor family CARD domain containing protei…

Perez-Lopez(Araceli),Rosales-Reyes(Roberto),… J Immunol 2013-03-26

...Hck, thus preventing the transcriptional activation of NLRC4. The ability of Salmonella to inhibit IL-1β production also...

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.

Saito(Yoriko),Yuki(Hitomi),Kuratani(Mitsuo),… Sci Transl Med 2013-12-05

...HCK), as a molecular target that is highly differentially expressed in human primary LSCs compared with human normal hem...

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