Itakura(Tomohiro),Kuroki(Aya),Ishibashi(Ya... Biol Pharm Bull 2006-10-18

...HEXB gene only was transfected. In contrast, a significant increase in the HexB (betabeta homodimer) activity toward neu...

Arfi(Audrey),Bourgoin(Christophe),Basso(Lu... Neurobiol Dis 2006-01-23

...HEXB cDNAs were constructed and tested on human Sandhoff fibroblasts. The bicistronic SIV.ASB vector enabled a massive r...

Ghanbari(Rasool),Shahbazi(Farhad) Phys Rev E Stat Nonlin Soft... 2006-03-07

...HexB transition could be due to the occurrence of this transition in the vicinity of a tricritical point.

Vallance(Hilary),Morris(Tara J),Coulter-Ma... Mol Genet Metab 2006-05-08

...HEXB polymorphisms: [619A>G (+) delTG]. To determine if these HEXB polymorphisms reduce HexA and HexB enzymatic activiti...

Denny(Christine A),Kasperzyk(Julie L),Gorh... J Neurosci Res 2006-07-13

...Hexb-/- mice. In addition, rotorod performance was significantly worse in the Hexb-/- mice than in the Hexb+/- mice. CR,...

Tsuji(Daisuke),Kuroki(Aya),Ishibashi(Yasuh... J Neurochem 2005-10-27

...HEXB) associated with simultaneous deficiencies of beta-hexosaminidase A (HexA; alphabeta) and B (HexB; betabeta), and e...

Kyrkanides(Stephanos),Miller(Jennie H),Bro... Brain Res Mol Brain Res 2005-05-09

...HexB-deficient (Sandhoff disease) mice following intraperitoneal administration to pups of neonatal age. Since brain inf...

Tsuji(Daisuke),Kuroki(Aya),Ishibashi(Yasuh... J Neurochem 2005-04-22

...HexB; betabeta), due to a primary defect of the beta-subunit gene (HEXB) associated with excessive accumulation of GM2 g...

Buccoliero(R),Ginzburg(L),Futerman(A H) J Inherit Metab Dis 2005-03-24

...Hexb mouse, a model of Sandhoff disease, lipid phosphate levels were elevated in surfactant from 3- and 4-month-old mice...

Andersson(Sofia V),Sjögren(Elsie C),Magnus... Glycobiology 2005-08-15

...HexB. HexA is an alpha beta-subunit heterodimer and HexB a beta-subunit homodimer. Both isoforms can remove nonreducing ...