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TP53 BRCA1 CRISPR single-cell cancer

Bai(Xiaofeng),Li(Peng),Xie(Yibin),Guo(Chun... Tumour Biol 0000-00-00

...PDK1 was analyzed by real-time quantitative PCR and immunohistochemistry method. Potential correlation between PDK1 prot...

Winfield(Leyte L),Smith(Dayle M),Halemano(... Lett Drug Des Discov 0000-00-00

PDK1 is pivotal in the development and progression of several cancers. A 3D pharmacophore was developed for pyrazole der...

Kanno(Takeshi),Tsuchiya(Ayako),Tanaka(Akit... Mol Neurobiol 0000-00-00

...PDK1)/Akt axis, to phosphorylate and inactivate GSK-3β. Combination of PKCε activation and PTP1B inhibition more suffici...

Huang(Tai-Qin),Zou(Min-Xu),Pasek(Daniel A)... J Receptor Ligand Channel R... 0000-00-00

...PDK1 at Ser-241, AKT at Thr-308, AMPK at Thr-172, and ERK1/2 at Thr-202/Tyr204. To confirm a role for mTOR signaling in ...

Dai(Qinsheng),Yin(Qian),Wei(Libin),Zhou(Yu... Mol Carcinog 0000-00-00

...PDK1, LDHA, and HK II), as well as their mRNA levels were also suppressed by oroxylin A under hypoxia. The silencing or ...

Wang(Hui),Zhang(Yujian),Lu(Yongning),Song(... Tumour Biol 0000-00-00

...PDK1. Significant differences were observed in the expression of p-AKT (at the Ser473 and Thr308 site), p-ERK, and two m...

Zhang(Bao-gui),Hu(Lei),Zang(Ming-de),Wang(... Oncotarget 0000-00-00

...PDK1 and AKT interaction and increased AKT phosphorylation. The P-AKT subsequent activated NFκB, which then bound to DNM...

McManus(Stephen),Bisson(Martine),Chamberla... J Bone Miner Res 0000-00-00

...PDK1) associates with the crucial adaptor p62 in OCs, we hypothesized that PDK1 may play an important role in OC-related...

Du(L),Chen(X),Cao(Y),Lu(L),Zhang(F),Bornst... Oncogene 0000-00-00

...PDK1) and enhanced transforming growth factor β (TGFβ) signaling rather than by AKT. Examination of human HNSCC clinical...

Saurus(Pauliina),Kuusela(Sara),Dumont(Vinc... Sci Rep 0000-00-00

...PDK1. Furthermore, PDK1 knockdown reduced the expression of CDK2 suggesting a regulatory loop between CDK2 and PDK1. Col...

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