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Single-cell RNA sequencing reveals extensive fibrotic remodeling and pathogen...

Nijiati(Y),Song(J),Huang(P),Lin(Z),Pei(Y),... Transl Pediatr 2026-04-30

...COL2A1, ACAN, CHAD, and CNMD. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed en...

Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartila...

Liu(T),Nan(K),Dang(X),Wang(W),Song(J) iScience 2026-09-18

...COL2A1⁺ chondrocytes (displaying a reparative hyaline cartilage phenotype) were significantly enriched in ONFH. Immunohi...

Magnetofection-mediated siRNA delivery ameliorates cartilage damage in Kashin...

Chen(Y),Wang(D),Zhang(Y),Liu(X),Du(Z),Chen... Theranostics None

...Col2a1). In vitro experiments were performed via pharmacological and genetic SIRT3 inhibition. To protect chondrocytes, ...

Transcriptomic comparison of the infrapatellar fat pad between young patients...

Li(T),Wang(P),Li(C),Chen(Y) Connect Tissue Res 2026-08-06

...COL2A1, and FN1. Additionally, core genes of the PI3K-Akt signaling pathway, such as AKT1, ITGA2B, and MYB, were also do...

Does integrin α10β1 enrichment improve cartilage regeneration? Insights from ...

Ayshath Ruksana(C),Aswin(M),Parasuraman(G)... Knee 2026-08-28

...COL2A1), hypertrophic markers (COL10A1, RUNX2), and matrix production (GAG/DNA, type II collagen ELISA). Functional outc...

Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 i...

Zhang(B),Fang(P),Long(J),Su(D),Liu(H),Weng... Bone Res 2026-09-02

...Col2a1-CreERT2/Erk5flox/flox mice, we found that Erk5 deletion in cartilage inhibited the progression of post-traumatic ...

Elevated DNA 5-hydroxymethylation promotes chondrocyte differentiation via TE...

Ullah(N),Jalil(F),Khan(MJ),Umair(M),Iqbal(... Histochem Cell Biol 2026-09-01

...COL2A1). Gene and protein expressions of TET1, TET2, TET3, and hTERT were analyzed through real-time polymerase chain re...

Lactate-driven lactylation reprograms chondrocyte fate and joint inflammation...

Liu(X),Hu(K),Bai(D) Front Cell Dev Biol 2026-00-00

...COL2A1 expression and enhance chondrocyte stress adaptation under specific post-traumatic and redox conditions. Lactylat...

Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating ...

Wang(Y),Wang(Y),Li(S),Chen(X),Hou(Y),Wang(... Front Pharmacol 2026-00-00

...COL2A1, and SOX9 expression and reduced IL-1β-induced increases in MMP13, ADAMTS5, COL10A1, RUNX2, and IL-6 immunoreacti...

Gene-activated porous scaffolds integrating SOX9 mRNA lipid nanoparticles ena...

Tan(S),Tsai(YC),Hung(PJ),Lin(YC),Chiang(CY... Int J Biol Macromol 2026-08-03

...COL2A1, while limiting fibrocartilage- and hypertrophy-associated markers. Transcriptomic analysis reveals that this res...

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