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Endometriosis and ovarian cancer: epidemiological evidence, molecular insight...

Leone Roberti Maggiore(U),Vignali(M),Kvask... Hum Reprod Update 2026-05-17

...KRAS are shared between endometriosis and certain OC subtypes, and the nature of the environment typical of ovarian endo...

Sotorasib induces intestinal epithelial injury through suppression of the cAM...

Chen(J),Liu(X),Wang(R),Li(J),Xu(Z),Yang(B)... Biochem Pharmacol 2026-09-00

...KRAS G12C inhibitor, has demonstrated substantial clinical efficacy in KRAS G12C-mutant malignancies but is frequently a...

Discovery of Novel ERK5 Inhibitors for Pancreatic Cancer via a Virtual Screen...

Zhang(J),Yang(X),Huang(B),Xu(Y),Geng(S),Zh... ACS Med Chem Lett 2026-02-12

...KRAS-mutant PDAC. To address the need for novel inhibitors, we implemented an integrated virtual screening workflow comb...

Structure-Guided Development of NRAS G12D Inhibitors Based on a 5‑Azaindole C...

Cox(JB),Nair(V),Mandal(P),Reyna(N),Tran(T)... ACS Med Chem Lett 2026-02-12

...KRAS proteins. Notably, stabilization of the p-loop and substitution toward Leu 95 while maintaining key interactions wi...

An Evaluation of Endobronchial Ultrasound-Transbronchial Needle Aspiration (E...

Wilkinson(W),Marshall(B),Banerjee(A) Cureus 2026-01-00

...KRAS G12C, and 15% (n = 3) were the EGFR E19del. Overall, 15.27% (n = 20) of EBUS-TBNA procedures for primary lung cance...

TP53 co-mutations are associated with elevated PD-L1 expression and high tumo...

Yang(Y),Zhuo(Z),Liu(C),Su(M),Zhao(X),Li(X) Transl Lung Cancer Res 2026-01-31

...KRAS (10.0%). EGFR mutations showed a strong female predominance (P<0.001), whereas MUC16 (P=0.004) and KRAS (P<0.001) a...

A CT imaging-based deep learning model for predicting EGFR and KRAS mutations...

Li(J),Xing(Y),Gao(X),Ye(Z),Wang(M),Song(F) Transl Lung Cancer Res 2026-01-31

...KRAS) affecting treatment response. While genetic testing remains the gold standard for mutation detection, it is invasi...

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in ...

Khoshkhoo(S),Bae(M),Wang(Y),Tillett(A),Ram... bioRxiv 2026-01-27

...KRAS, and twelve genes not previously associated with focal epilepsy. Eight Ras-MAPK genes showed positive clonal select...

Transgenic mouse model of congenital choledochal cyst.

Rinehardt(HN),Martyn(A),Kolodychak(A),Take... Pediatr Surg Int 2026-02-25

...Kras G12D Mu/Wt. Control C57 mice were used as a comparison. Experimental and control mice underwent serial abdominal ma...

CRISPR/Cas9 in Cancer Therapy: Precision Genome Editing Approaches Targeting ...

Joshi(D),Kshatri(P),Tiwari(A),Bhardwaj(U),... Cell Biochem Biophys 2026-06-00

...KRAS, MYC, BRAF, and EGFR, and restoring the function of tumor suppressors including TP53, RB1, and PTEN. The review fur...

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