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Physiologically-based pharmacokinetic modeling to evaluate in vitro-to-in vivo …

Yamazaki(S),Evers(R),De Zwart(L) CPT Pharmacometrics Syst Phar… 2022-00-00

...Pgp, ABCB1)-mediated DDIs among three Pgp substrates, digoxin, dabigatran etexilate, and quinidine, and two Pgp inhibito...

Differential expression of P-glycoprotein genes in primary rat hepatocyte cultu…

Lee(C H),Bradley(G),Zhang(J T),Ling(V) J Cell Physiol 1993-12-01

...Pgp expression in rat liver can be perturbed in vivo and in vitro; however, it is not known which of the 3 Pgp genes (cl...

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein…

Dantzig(A H),Shepard(R L),Law(K L),Tabas(L),… J Pharmacol Exp Ther 1999-08-18

...Pgp for LY335979. The modulator's effect on Pgp was evaluated with Pgp-overexpressing CEM/vinblastine (VLB)(100) and par...

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma me…

Luker(G D),Nilsson(K R),Covey(D F),Piwnica-W… J Biol Chem 1999-04-13

...Pgp) confer multidrug resistance in tumors, but the physiologic function of Pgp in normal tissues remains uncertain. In ...

Effects of MDR1/P-glycoprotein expression on prognosis in advanced colorectal c…

Tokunaga(Y),Hosogi(H),Hoppou(T),Nakagami(M),… Oncol Rep 2001-08-23

...Pgp (+) than Pgp (-) patients. Pgp was not a significant prognostic factor by univariate analysis and multivariate analy...

P-glycoprotein in HK-2 proximal tubule cell line.

Tramonti(G),Romiti(N),Norpoth(M),Chieli(E) Ren Fail 2001-12-28

...PGP) is an efflux pump physiologically expressed in the apical membrane of the proximal tubular cells. PGP may play a ro...

Clinical modulation of multidrug resistance in multiple myeloma: effect of cycl…

Sonneveld(P),Schoester(M),de Leeuw(K) J Clin Oncol 1994-08-25

...Pgp-positive (Pgp+) PC was 30% to 100% (median, 90%) before treatment and 4 to 90% (median, 40%) after treatment. CD56+/...

Duplication and evolution of the P-glycoprotein genes in pig.

Childs(S),Ling(V) Biochim Biophys Acta 1996-08-20

...Pgp's. We demonstrate expression of Class I pgp in pig brain cultured capillary endothelial cells, and Class III pgp in ...

Evidence for a "new" allele at the phosphoglycolate phosphatase locus.

Henke(J),Schweitzer(H),Sachs(V) Hum Genet 1985-00-00

...PGP) gene product (PGP Sumatra) was detected by use of horizontal starch gel electrophoresis (SGE). The observed phenoty...

Direct demonstration of high affinity interactions of immunosuppressant drugs w…

Rao(U S),Scarborough(G A) Mol Pharmacol 1994-06-16

...Pgp function. The macrolides FK506 and FK520 stimulate the Pgp-ATPase activity with affinities in the 100 nM range, near...

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